Floating Alginate Microbeads of Sumatriptan Succinate: Formulation, Development, Evaluation - Couverture souple

Jagdale, Swati; Patil, Satej

 
9783659633980: Floating Alginate Microbeads of Sumatriptan Succinate: Formulation, Development, Evaluation
Couverture souple
ISBN 10 : 3659633984 ISBN 13 : 9783659633980
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

Sumatriptan succinate is effective in ∼70% of migraine attacks but has short duration of action and low oral bio-availability due to first pass metabolism. It has elimination half-life of 2.5 hours and has absorption zone from stomach and upper part of small intestinal tract. In present study floating alginate microbeads system has been designed for gastro retention. Sodium alginate (low methoxy grade), HPMC K15M and Pluronic F127 were selected for preparation of microbeads of Sumatriptan succinate. Sumatriptan succinate loaded microbeads were prepared using ionotrophic gelation method. The effect of various process variables as Stirring Speed, Needle size, Dropping distance, Medium for gelation, Gelation time as well as formulation variables were studied. Prepared microbeads were evaluated for micromeritic properties, percentage microbeads yield, percent floating capacity, percent drug entrapment efficiency and percent drug release. In the present book Optimization of process variable and formulation variable of microbeads were carried out. The book will be useful for the researchers working in the areas of formulation development of Pharmaceuticals.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Sumatriptan succinate is effective in ∼70% of migraine attacks but has short duration of action and low oral bio-availability due to first pass metabolism. It has elimination half-life of 2.5 hours and has absorption zone from stomach and upper part of small intestinal tract. In present study floating alginate microbeads system has been designed for gastro retention. Sodium alginate (low methoxy grade), HPMC K15M and Pluronic F127 were selected for preparation of microbeads of Sumatriptan succinate. Sumatriptan succinate loaded microbeads were prepared using ionotrophic gelation method. The effect of various process variables as Stirring Speed, Needle size, Dropping distance, Medium for gelation, Gelation time as well as formulation variables were studied. Prepared microbeads were evaluated for micromeritic properties, percentage microbeads yield, percent floating capacity, percent drug entrapment efficiency and percent drug release. In the present book Optimization of process variable and formulation variable of microbeads were carried out. The book will be useful for the researchers working in the areas of formulation development of Pharmaceuticals.

Biographie de l'auteur

Dr.Swati Jagdale M.Pharm, Ph.D, M.B.A; Studied at University of Pune. She is presently working as Professor and Head, Department of Pharmaceutics at MAEER’s Maharashtra Institute of Pharmacy,MIT Campus, Kothrud, Pune, (MS), India.She has 14 years of academic experience. She has expertise in field of formulation development of Pharmaceutical

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659633984
ISBN 13 
9783659633980
Reliure
Broché
Nombre de pages
120
Coordonnées du fabricant
non disponible
Personne responsable
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