Structure and Functional Correlations of Human Glucokinase - Couverture souple

Yellapu, Nanda Kumar; P.V.G.K., Sarma; Matcha, Bhaskar

 
9783659635533: Structure and Functional Correlations of Human Glucokinase
Couverture souple
ISBN 10 : 3659635537 ISBN 13 : 9783659635533
Editeur : LAP LAMBERT Academic Publishing, 2016

Synopsis

Glucokinase plays a critical role in glucose homeostasis and the mutations in Glucokinase gene results in altered catalysis of the enzyme leading to type 2 diabetic condition. The catalysis takes place by super open and closed conformations of enzyme which will be disturbed by the mutations. The in silico mutagenic studies reveal several mysterious points about the impact of mutations on the structural and functional behaviour of glucokinase that are in best correlation with its enzyme activities. This study provides an insight into the understanding of the clear possible reasons for the altered activities of glucokinase under mutated condition and the probable consequences with respect to the pathogenesis of diabetes. This problem can be solved by the usage of glucokinase activators that have the ability to bind with the allosteric site of glucokinase and increase its activity by specific folds. Structure based drug design helps to develop more efficient lead molecules based on the structural information of the glucokinase. These molecules can be used to for the treatment and management of type 2 diabetes.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Glucokinase plays a critical role in glucose homeostasis and the mutations in Glucokinase gene results in altered catalysis of the enzyme leading to type 2 diabetic condition. The catalysis takes place by super open and closed conformations of enzyme which will be disturbed by the mutations. The in silico mutagenic studies reveal several mysterious points about the impact of mutations on the structural and functional behaviour of glucokinase that are in best correlation with its enzyme activities. This study provides an insight into the understanding of the clear possible reasons for the altered activities of glucokinase under mutated condition and the probable consequences with respect to the pathogenesis of diabetes. This problem can be solved by the usage of glucokinase activators that have the ability to bind with the allosteric site of glucokinase and increase its activity by specific folds. Structure based drug design helps to develop more efficient lead molecules based on the structural information of the glucokinase. These molecules can be used to for the treatment and management of type 2 diabetes.

Biographie de l'auteur

Dr. Nanda Kumar Yellapu is a Bioinformatics Scientist at Biomedical Informatics Centre of Vector Control Research Centre (ICMR), Pondicherry, India. He obtained his Masters degree from SVIMS University and PhD from Sri Venkateswara University, Tirupati, India. His research focuses on the protein conformational studies and drug discovery strategies.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2016
Langue
anglais
ISBN 10 
3659635537
ISBN 13 
9783659635533
Reliure
Broché
Nombre de pages
172
Coordonnées du fabricant
non disponible
Personne responsable
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