Articles liés à Quinazolines as potential bioactive agents: Biological...

Quinazolines as potential bioactive agents: Biological Potential of Quinazolines - Couverture souple

Patel, Amit B.; Chikhalia, Kishor; Kumari, Premlata

 
9783659638114: Quinazolines as potential bioactive agents: Biological Potential of Quinazolines
Couverture souple
ISBN 10 : 3659638110 ISBN 13 : 9783659638114
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

The proposed book gives an outline of the design, synthesis, characterization and various biological activities (antibacterial, antifungal, antituberculosis and anticancer) of novel urea/thiaourea functionalized quinazoline scaffolds. We have developed an efficient technique to introduced Suzuki C-C reaction on quinazoline and urea/thiourea moieties. The antimicrobial activity of synthesized analogs has been carried out against two Gram-positive bacteria, three Gram-negative bacteria and two fungi using paper disc diffusion method and agar streak dilution method. The synthesized analogs were further tested for their antimycobacterial activity against Mycobacterium tuberculosis H37RV using BACTEC MGIT and L. J. MIC methods. In addition, the synthesized analogs were also tested for their efficacy against prostate cancer PC3 cells using sulforhodamine B (SRB) assay to observe the variation in biological activity. The bioassay results revealed that majority of the compounds demonstrated excellent to moderate biological activity profiles. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectrometric analysis.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The proposed book gives an outline of the design, synthesis, characterization and various biological activities (antibacterial, antifungal, antituberculosis and anticancer) of novel urea/thiaourea functionalized quinazoline scaffolds. We have developed an efficient technique to introduced Suzuki C-C reaction on quinazoline and urea/thiourea moieties. The antimicrobial activity of synthesized analogs has been carried out against two Gram-positive bacteria, three Gram-negative bacteria and two fungi using paper disc diffusion method and agar streak dilution method. The synthesized analogs were further tested for their antimycobacterial activity against Mycobacterium tuberculosis H37RV using BACTEC MGIT and L. J. MIC methods. In addition, the synthesized analogs were also tested for their efficacy against prostate cancer PC3 cells using sulforhodamine B (SRB) assay to observe the variation in biological activity. The bioassay results revealed that majority of the compounds demonstrated excellent to moderate biological activity profiles. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectrometric analysis.

Biographie de l'auteur

Dr. Amit B. Patel is currently working as an Asst. Professor at H.V.H.P. Institute of Postgraduate Studies and Research, KSV University, Kadi, India. His research interest mainly concerned with the development of new Transition-Metal mediated cross coupling reactions of variety of new organic and heterocyclic scaffolds.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659638110
ISBN 13 
9783659638114
Reliure
Broché
Nombre de pages
64
Coordonnées du fabricant
non disponible
Personne responsable
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