Articles liés à Synthesis and characterization of Triazolo[4,3-c]pyrimidine...

Synthesis and characterization of Triazolo[4,3-c]pyrimidine library - Couverture souple

Vilapara, Dr. Kalpesh; Gami, Dr. Sagar

 
9783659639852: Synthesis and characterization of Triazolo[4,3-c]pyrimidine library

Synopsis

A novel [1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamide libraries were synthesized via oxidative cyclization of hydrazono-1,6-dihydropyrimidine-5-carboxamide intermediates by the application of Iodobenzenediacetate as a sole cyclizating agent. Here, we report one pot sequential strategy to generate corresponding triazolopyrimidines by condensation of preprepared α-acylketene dithioacetals and arylamidines. Moreover, this process describes the application of presynthesized arylamidines which omits the transition metal catalyzed Suzuki-Miyaura cross coupling reaction hence signify the atom- and step-economic methodology.

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