Biochemical study of Autism Spectrum Disorder patients - Couverture souple

Abdul Aziz Al-Ameen, Safaa; Ahmad, Tareq Younis; Tawfiq, Fadwa Khalid

 
9783659642579: Biochemical study of Autism Spectrum Disorder patients
Couverture souple
ISBN 10 : 3659642576 ISBN 13 : 9783659642579
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

Many hypotheses were supposed as autism spectrum disorder(ASD)causes. Dipeptidyl peptidase-4 deficiency and opioids compounds formation, oxidative stress and environmental toxicants exposure were studied. So many biochemical parameters as Melatonin (MEL), Neuroglobin(NGB),Antioxidant Activity(AOA), Advanced Oxidation Protein Products (AOPP), Thiobarbituric Acid Reactive Substances (TBARS), Nitric Oxide(No), Glutathione (GSH) were studied. Also, Dipeptidyl Peptidase-4(DPP-4), Glutathione-S-Transferase(GST), Acetyl Cholinesterase (AChE), Myeloperoxidase (MPO), Aryl Esterase, Xanthine Oxidase (XO)activities were estimated. Many techniques were used in this study such as HPLC, SDS-PAGE and gel filtration chromatography,protein precipitation,dialysis, molecular weight determination,estimation of total protein by modified Lowry and studying the optimum conditions of serum DPP-4. The future studies must include studying the Genetic factors. Mutations of DPP-4, ASMT, MTHFR, COMT in autistic children must be studied since mutation in these enzymes might be involved in ASD. Also, estimation of the levels of serum testosterone, secretin and metallothionein in ASD patients must be studied.

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Présentation de l'éditeur

Many hypotheses were supposed as autism spectrum disorder(ASD)causes. Dipeptidyl peptidase-4 deficiency and opioids compounds formation, oxidative stress and environmental toxicants exposure were studied. So many biochemical parameters as Melatonin (MEL), Neuroglobin(NGB),Antioxidant Activity(AOA), Advanced Oxidation Protein Products (AOPP), Thiobarbituric Acid Reactive Substances (TBARS), Nitric Oxide(No), Glutathione (GSH) were studied. Also, Dipeptidyl Peptidase-4(DPP-4), Glutathione-S-Transferase(GST), Acetyl Cholinesterase (AChE), Myeloperoxidase (MPO), Aryl Esterase, Xanthine Oxidase (XO)activities were estimated. Many techniques were used in this study such as HPLC, SDS-PAGE and gel filtration chromatography,protein precipitation,dialysis, molecular weight determination,estimation of total protein by modified Lowry and studying the optimum conditions of serum DPP-4. The future studies must include studying the Genetic factors. Mutations of DPP-4, ASMT, MTHFR, COMT in autistic children must be studied since mutation in these enzymes might be involved in ASD. Also, estimation of the levels of serum testosterone, secretin and metallothionein in ASD patients must be studied.

Biographie de l'auteur

Safaa Abdul aziz Al-ameen B.Sc in Chemistry from Science college/Mosul university in 1994 M.Sc in Biochemistry from Science college/Mosul university in 2001 Ph.D in Biochemistry from Science college/Mosul university in 2014 I work as lecturer in chem.Dept. The research was achieved by two supervisors (Prof.Dr.Tareq Y.Ahmad & Prof.Dr.Fadwa K.Tawfiq

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659642576
ISBN 13 
9783659642579
Reliure
Broché
Nombre de pages
184
Coordonnées du fabricant
non disponible
Personne responsable
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