Articles liés à CB1 Receptor Modulation Against Parkinson’s...

CB1 Receptor Modulation Against Parkinson’s disease in Rats - Couverture souple

Deshmukh, Rahul; Prabhakar, Mayank; Kumar, Puneet

 
9783659645860: CB1 Receptor Modulation Against Parkinson’s disease in Rats
Couverture souple
ISBN 10 : 3659645869 ISBN 13 : 9783659645860
Editeur : LAP LAMBERT Academic Publishing, 2014

Synopsis

Recently, the controversial role of cannabinoid receptors was reported in the pathophysiology of PD. In the present study we have investigated the role of CB1 receptors in motor behaviour. Repeated intranigral (day 1, 7, 14) infusion of MPTP was done to produce stable motor deficits in rats. CB1 receptor agonist, Noladin ether and antagonist AM 251, was administered alone or in combination in MPTP-infused rats. Grip strength, spontaneous locomotor activity and narrow beam walk tests were used to access motor behaviours. Oxidative stress and pro-inflammatory cytokine levels were determined in striatal brain homogenates. MPTP-infused rats showed stable motor deficit and elevation in oxidative stress and cytokine levels. AM 251 attenuated MPYP-induced motor dysfunction, oxidative stress and neuroinflammation in rats. Conversely, noladin ether synergized MPTP- mediated neurotoxicity, which was significantly attenuated by AM 251 pre-treatment. The above results suggests that sustained activation of CB1 receptors may play a crucial role in the development motor dysfunction and thus CB1 receptor blockade would be therapeutic in PD.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Recently, the controversial role of cannabinoid receptors was reported in the pathophysiology of PD. In the present study we have investigated the role of CB1 receptors in motor behaviour. Repeated intranigral (day 1, 7, 14) infusion of MPTP was done to produce stable motor deficits in rats. CB1 receptor agonist, Noladin ether and antagonist AM 251, was administered alone or in combination in MPTP-infused rats. Grip strength, spontaneous locomotor activity and narrow beam walk tests were used to access motor behaviours. Oxidative stress and pro-inflammatory cytokine levels were determined in striatal brain homogenates. MPTP-infused rats showed stable motor deficit and elevation in oxidative stress and cytokine levels. AM 251 attenuated MPYP-induced motor dysfunction, oxidative stress and neuroinflammation in rats. Conversely, noladin ether synergized MPTP- mediated neurotoxicity, which was significantly attenuated by AM 251 pre-treatment. The above results suggests that sustained activation of CB1 receptors may play a crucial role in the development motor dysfunction and thus CB1 receptor blockade would be therapeutic in PD.

Biographie de l'auteur

Dr. Rahul Deshmukh, is serving as Associate Professor & HOD Pharmacology at ISFCP, Moga, Punjab; India. His major research area include cognitive and motor disorders. Dr. Deshmukh has clinched several research grants and awarded as a Young Scientist by DST, India. He gave invited talks & presented papers in national and international conferences.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2014
Langue
anglais
ISBN 10 
3659645869
ISBN 13 
9783659645860
Reliure
Broché
Nombre de pages
108
Coordonnées du fabricant
non disponible
Personne responsable
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