Articles liés à Regulation of nuclear import of LIM-Kinase 2 in endothelial...
Synopsis
The activation of the endothelium with various stimuli such as thrombin leads to cell shape change, migration, and proliferation that involve dynamic changes of the actin cytoskeleton. The Rho family GTPases activate Rho-kinase and PAK, which stimulate LIM-kinases. LIM-kinases regulate the actin cytoskeleton through phosphorylation of cofilin. Only very few studies reported about other functions of LIM-kinases, such as its possible role in cell cycle regulation. The function of the LIM-kinases is unknown in endothelial cells. In this study, we answered the following questions: 1. Which LIM-kinase(s) are expressed in endothelial cells? What is the role of LIM-kinases and cofilin phosphorylation in thrombin-induced stress fiber formation and contraction of endothelial cells? How is the LIMK/cofilin pathway regulated in endothelial cells? 2. Does LIMK2 shuttle between the cytosol and the nucleus in endothelial cells? If yes, which are the responsible nuclear localization signals (NLSs) and nuclear export signals (NESs)? How is the nucleocytoplasmic shuttling of LIMK2 regulated in endothelial cells?
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Regulation of nuclear import of LIM-Kinase 2 in endothelial cells
Edité par
LAP LAMBERT Academic Publishing Aug 2015, 2015
ISBN 10 : 3659764639
ISBN 13 : 9783659764639
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The activation of the endothelium with various stimuli such as thrombin leads to cell shape change, migration, and proliferation that involve dynamic changes of the actin cytoskeleton. The Rho family GTPases activate Rho-kinase and PAK, which stimulate LIM-kinases. LIM-kinases regulate the actin cytoskeleton through phosphorylation of cofilin. Only very few studies reported about other functions of LIM-kinases, such as its possible role in cell cycle regulation. The function of the LIM-kinases is unknown in endothelial cells. In this study, we answered the following questions: 1. Which LIM-kinase(s) are expressed in endothelial cells What is the role of LIM-kinases and cofilin phosphorylation in thrombin-induced stress fiber formation and contraction of endothelial cells How is the LIMK/cofilin pathway regulated in endothelial cells 2. Does LIMK2 shuttle between the cytosol and the nucleus in endothelial cells If yes, which are the responsible nuclear localization signals (NLSs) and nuclear export signals (NESs) How is the nucleocytoplasmic shuttling of LIMK2 regulated in endothelial cells 152 pp. Englisch. N° de réf. du vendeur 9783659764639
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Regulation of nuclear import of LIM-Kinase 2 in endothelial cells
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LAP LAMBERT Academic Publishing, 2015
ISBN 10 : 3659764639
ISBN 13 : 9783659764639
Neuf
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Vendeur : moluna, Greven, Allemagne
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Goyal PankajDr Pankaj Goyal is currently an Associate Professor in the Department of Biotechnology, at theCentral University of Rajasthan, India. He received his PhD in Human Biology from the Institute for Prevention of Cardiovascula. N° de réf. du vendeur 158605210
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Regulation of nuclear import of LIM-Kinase 2 in endothelial cells
Edité par
LAP LAMBERT Academic Publishing, 2015
ISBN 10 : 3659764639
ISBN 13 : 9783659764639
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - The activation of the endothelium with various stimuli such as thrombin leads to cell shape change, migration, and proliferation that involve dynamic changes of the actin cytoskeleton. The Rho family GTPases activate Rho-kinase and PAK, which stimulate LIM-kinases. LIM-kinases regulate the actin cytoskeleton through phosphorylation of cofilin. Only very few studies reported about other functions of LIM-kinases, such as its possible role in cell cycle regulation. The function of the LIM-kinases is unknown in endothelial cells. In this study, we answered the following questions: 1. Which LIM-kinase(s) are expressed in endothelial cells What is the role of LIM-kinases and cofilin phosphorylation in thrombin-induced stress fiber formation and contraction of endothelial cells How is the LIMK/cofilin pathway regulated in endothelial cells 2. Does LIMK2 shuttle between the cytosol and the nucleus in endothelial cells If yes, which are the responsible nuclear localization signals (NLSs) and nuclear export signals (NESs) How is the nucleocytoplasmic shuttling of LIMK2 regulated in endothelial cells. N° de réf. du vendeur 9783659764639
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Regulation of nuclear import of LIM-Kinase 2 in endothelial cells
Edité par
LAP LAMBERT Academic Publishing Aug 2015, 2015
ISBN 10 : 3659764639
ISBN 13 : 9783659764639
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -The activation of the endothelium with various stimuli such as thrombin leads to cell shape change, migration, and proliferation that involve dynamic changes of the actin cytoskeleton. The Rho family GTPases activate Rho-kinase and PAK, which stimulate LIM-kinases. LIM-kinases regulate the actin cytoskeleton through phosphorylation of cofilin. Only very few studies reported about other functions of LIM-kinases, such as its possible role in cell cycle regulation. The function of the LIM-kinases is unknown in endothelial cells. In this study, we answered the following questions: 1. Which LIM-kinase(s) are expressed in endothelial cells What is the role of LIM-kinases and cofilin phosphorylation in thrombin-induced stress fiber formation and contraction of endothelial cells How is the LIMK/cofilin pathway regulated in endothelial cells 2. Does LIMK2 shuttle between the cytosol and the nucleus in endothelial cells If yes, which are the responsible nuclear localization signals (NLSs) and nuclear export signals (NESs) How is the nucleocytoplasmic shuttling of LIMK2 regulated in endothelial cells VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 152 pp. Englisch. N° de réf. du vendeur 9783659764639
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Regulation of nuclear import of LIM-Kinase 2 in endothelial cells
Edité par
LAP LAMBERT Academic Publishing, 2015
ISBN 10 : 3659764639
ISBN 13 : 9783659764639
Neuf
Taschenbuch
Vendeur : preigu, Osnabrück, Allemagne
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Taschenbuch. Etat : Neu. Regulation of nuclear import of LIM-Kinase 2 in endothelial cells | Pankaj Goyal | Taschenbuch | 152 S. | Englisch | 2015 | LAP LAMBERT Academic Publishing | EAN 9783659764639 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. N° de réf. du vendeur 104209634
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Regulation of nuclear import of LIM-Kinase 2 in endothelial cells
Edité par
LAP LAMBERT Academic Publishing, 2015
ISBN 10 : 3659764639
ISBN 13 : 9783659764639
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paperback. Etat : Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book. N° de réf. du vendeur ERICA80036597646396
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