Formulation and evaluation mouth dissolving tablets of Tramadol HCL - Couverture souple

Ponugoti, Raja Sridhar Rao; Gonugunta, Chandrashekara Rao

 
9783659766916: Formulation and evaluation mouth dissolving tablets of Tramadol HCL
Couverture souple
ISBN 10 : 3659766917 ISBN 13 : 9783659766916
Editeur : LAP Lambert Academic Publishing, 2015

Synopsis

According to United States Pharmacopoeia, the orodispersible tablets may be defined as solid dosage form containing medicinal substance or active ingredient which disintegrates rapidly within a matter of seconds when placed upon the tongue. This means that the tablets dissolve or disintegrate in the oral cavity without use of water. In this regard, the tablets need to improve disintegration time, dispersion time, drug release studies, bioavailability and patient compliance and also need to mask the bitter taste of the drug and to maintain the drug stable at accelerated condition i.e. 40C/75% RH up to 6 months period as per ICH guidelines. Tramadol HCl is centrally acting synthetic opioid analgesic for the treatment of moderate to severe pain and is readily soluble in water. The half life of the drug is around 5.5 hours. The MDT's place a major role for rapid onset of action for geriatrics, pediatrics and the patients who have less access of water. The drug itself having bitter taste, so the present authors developed mouth dissolving tablets of tramadol HCl with the aim to mask the bitter taste of the drug, to minimize the disintegration time and improve the drug release rate.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

According to United States Pharmacopoeia, the orodispersible tablets may be defined as solid dosage form containing medicinal substance or active ingredient which disintegrates rapidly within a matter of seconds when placed upon the tongue. This means that the tablets dissolve or disintegrate in the oral cavity without use of water. In this regard, the tablets need to improve disintegration time, dispersion time, drug release studies, bioavailability and patient compliance and also need to mask the bitter taste of the drug and to maintain the drug stable at accelerated condition i.e. 40C/75% RH up to 6 months period as per ICH guidelines. Tramadol HCl is centrally acting synthetic opioid analgesic for the treatment of moderate to severe pain and is readily soluble in water. The half life of the drug is around 5.5 hours. The MDT's place a major role for rapid onset of action for geriatrics, pediatrics and the patients who have less access of water. The drug itself having bitter taste, so the present authors developed mouth dissolving tablets of tramadol HCl with the aim to mask the bitter taste of the drug, to minimize the disintegration time and improve the drug release rate.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP Lambert Academic Publishing
Date d'édition
2015
Langue
anglais
ISBN 10 
3659766917
ISBN 13 
9783659766916
Reliure
Broché
Nombre de pages
60
Coordonnées du fabricant
non disponible
Personne responsable
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