Dynamics-based Computational Design of Anti-Cancer Drugs: An Emerging Approach to Drug Design - Couverture souple

Fatima, Talath; Ahmed, Osman

 
9783659785412: Dynamics-based Computational Design of Anti-Cancer Drugs: An Emerging Approach to Drug Design
Couverture souple
ISBN 10 : 3659785415 ISBN 13 : 9783659785412
Editeur : LAP LAMBERT Academic Publishing, 2017

Synopsis

Computational drug design approach has a great potential in accelerating the drug discovery process. Structure-based drug design and ligand-based drug design are the two broad classes of computational drug design. Cancer is a class of highly complex diseases involving multiple genes and multiple cross-talks between signaling networks. Cancer cells may be developed from inherited defects or acquired damages of DNA. However, many cancers are resistant to treatment, and metastasis of cancers makes the disease even more intractable. Secondary malignancies are frequently observed after cancer chemotherapy. The call for more effective cancer therapy is obligatory. Using drug-cocktails that combine multiple anti-cancer agents working in different mechanisms has been a standard treatment of cancers to overcome the drug resistance problem. More recently, design of multiple ligands (may be more easily understood as “multiple target ligands”), i.e., single agents that target multiple biomolecules in a rational manner, receives increasing attention. Some recent methodological developments on computational drug design are reviewed, and a few recent drug design efforts in cancer is summarized.

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Présentation de l'éditeur

Computational drug design approach has a great potential in accelerating the drug discovery process. Structure-based drug design and ligand-based drug design are the two broad classes of computational drug design. Cancer is a class of highly complex diseases involving multiple genes and multiple cross-talks between signaling networks. Cancer cells may be developed from inherited defects or acquired damages of DNA. However, many cancers are resistant to treatment, and metastasis of cancers makes the disease even more intractable. Secondary malignancies are frequently observed after cancer chemotherapy. The call for more effective cancer therapy is obligatory. Using drug-cocktails that combine multiple anti-cancer agents working in different mechanisms has been a standard treatment of cancers to overcome the drug resistance problem. More recently, design of multiple ligands (may be more easily understood as “multiple target ligands”), i.e., single agents that target multiple biomolecules in a rational manner, receives increasing attention. Some recent methodological developments on computational drug design are reviewed, and a few recent drug design efforts in cancer is summarized.

Biographie de l'auteur

Talath Fatima is a Pharmacy graduate Student at Deccan School of Pharmacy, Hyderabad.She serves as one of the youngest Editorial Advisor in four Pharmaceutical journals.Dr. Osman Ahmed is an elite Professor in Pharmaceutical Chemistry and Vice-Principal of Deccan School of Pharmacy.He has done appreciable research work in the field of Pharmacy.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2017
Langue
anglais
ISBN 10 
3659785415
ISBN 13 
9783659785412
Reliure
Broché
Nombre de pages
104
Coordonnées du fabricant
non disponible
Personne responsable
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