Dual Drug Action of Drug Delivery System - Couverture souple

Biswal, Pramod Kumar; Mishra, Manoj Kumar; Bhaodouriya, Anupam Singh

 
9783659787454: Dual Drug Action of Drug Delivery System
Couverture souple
ISBN 10 : 3659787450 ISBN 13 : 9783659787454
Editeur : LAP LAMBERT Academic Publishing, 2015

Synopsis

The purpose of the present research was to produce a quick/slow biphasic delivery system for Diclofenac Sodium. A dual component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (Diclofenac Sodium). The sustained release effect was achieved with a polymer (Microcrystalline cellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the Diclofenac Sodium contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (≈16 or 924 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the Micro Crystalline core was suitable for providing a constant and controlled release (zero order) for a long period of time.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The purpose of the present research was to produce a quick/slow biphasic delivery system for Diclofenac Sodium. A dual component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (Diclofenac Sodium). The sustained release effect was achieved with a polymer (Microcrystalline cellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the Diclofenac Sodium contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (≈16 or 924 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the Micro Crystalline core was suitable for providing a constant and controlled release (zero order) for a long period of time.

Biographie de l'auteur

I am Pramod Kumar Biswal, currently working as Assistant Professor in Kunuwar Haribansh Singh college of Pharmacy, Jaunpur, U.P., India.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2015
Langue
anglais
ISBN 10 
3659787450
ISBN 13 
9783659787454
Reliure
Broché
Nombre de pages
80
Coordonnées du fabricant
non disponible
Personne responsable
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