In Search of Selective 11β-HSD 1 Inhibitors without Nephrotoxicity: An Approach to Resolve the Metabolic Syndrome by Virtual Based Screening - Couverture souple

Jagtap, Rakesh; Patel, Harun; Dhangar, Kiran

 
9783659790010: In Search of Selective 11β-HSD 1 Inhibitors without Nephrotoxicity: An Approach to Resolve the Metabolic Syndrome by Virtual Based Screening
Couverture souple
ISBN 10 : 365979001X ISBN 13 : 9783659790010
Editeur : LAP LAMBERT Academic Publishing, 2015

Synopsis

Over expression of 11β-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11β-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11β-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11β-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski’s rule and ADME prediction implemented to find out the potent and selective 11 β-HSD 1 analog of corosolic acid without nephrotoxicity.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Over expression of 11β-HSD 1 in key metabolic tissues is related to the development of type 2 diabetes, obesity, hypertension and metabolic syndrome. Nephrotoxicity of corosolic acid (selective inhibitor of 11β-HSD 1) is recently reported, which is one of the major drawback. Therefore, it is of great interest to find out the selective 11β-HSD 1 inhibitors without nephrotoxicity. Using crystal structures of 11β-HSD 1 in complex with inhibitors as a source of structural information, a combined structure-based virtual screening approach followed by PASS toxicity prediction, Lipinski’s rule and ADME prediction implemented to find out the potent and selective 11 β-HSD 1 analog of corosolic acid without nephrotoxicity.

Biographie de l'auteur

Mr. Rakesh has completed the Bachelor Degree of Pharmacy in year 2014. He recently doing his Masters of Pharmacy with India's best institute R. C. P. Institute of Pharmaceutical Education and Research, Shirpur. His recent published work is "Structural Insight of Glitazone for Hepato-toxicity: Resolving Mystery by PASS".

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2015
Langue
anglais
ISBN 10 
365979001X
ISBN 13 
9783659790010
Reliure
Broché
Nombre de pages
56
Coordonnées du fabricant
non disponible
Personne responsable
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