Homology Modeling of Human NK-1 Receptor and Docking Study: Structure Based Drug Design - Couverture souple

Gupta, Manish K.; Kumar, Viney

 
9783659804205: Homology Modeling of Human NK-1 Receptor and Docking Study: Structure Based Drug Design
Couverture souple
ISBN 10 : 3659804207 ISBN 13 : 9783659804205
Editeur : LAP LAMBERT Academic Publishing, 2015

Synopsis

Neurokinin-1 (NK-1) receptor regulates many biological functions related to cancer, such as tumor cell proliferation, angiogenesis and migration of tumor cells for invasion and metastasis. The NK-1 receptor antagonists specifically inhibit tumor cell proliferation, migration of the tumor cells and show antiangiogenic effect. Therefore, the development of NK-1 antagonists for the treatment of cancer is of current interest. The 3D structure of NK-1 is not available from protein data bank. This hampers the design of selective NK-1 antagonists. This book describes the homology modeling of the human NK-1 receptor using multiple templates to provide structural basis for the design of new NK-1 inhibitors and anticancer agents. The authors anticipate that the book will be very useful for the researchers who are working on the design and development of NK-1 receptor antagonists and anticancer agents.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Neurokinin-1 (NK-1) receptor regulates many biological functions related to cancer, such as tumor cell proliferation, angiogenesis and migration of tumor cells for invasion and metastasis. The NK-1 receptor antagonists specifically inhibit tumor cell proliferation, migration of the tumor cells and show antiangiogenic effect. Therefore, the development of NK-1 antagonists for the treatment of cancer is of current interest. The 3D structure of NK-1 is not available from protein data bank. This hampers the design of selective NK-1 antagonists. This book describes the homology modeling of the human NK-1 receptor using multiple templates to provide structural basis for the design of new NK-1 inhibitors and anticancer agents. The authors anticipate that the book will be very useful for the researchers who are working on the design and development of NK-1 receptor antagonists and anticancer agents.

Biographie de l'auteur

Manish Kumar Gupta (M. Pharm., PhD., Postdoc): Professor of Pharmacy, Lloyd Inst. of Mang. & Tech. Gr. Noida, India. His research work focuses on the ligand and structure based drug design, protein modeling and molecular dynamics simulation studies. He has published several research papers in peer-reviewed journals of ACS, Springer and Elsevier.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2015
Langue
anglais
ISBN 10 
3659804207
ISBN 13 
9783659804205
Reliure
Broché
Nombre de pages
92
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne