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Systems Biology & Functional Genomics for Precision Medicine: A Data-Driven and Integrative Approach - Couverture souple

Yu, Jiyang

 
9783659806438: Systems Biology & Functional Genomics for Precision Medicine: A Data-Driven and Integrative Approach
Couverture souple
ISBN 10 : 3659806439 ISBN 13 : 9783659806438
Editeur : LAP LAMBERT Academic Publishing, 2015

Synopsis

Data-driven personalized or precision medicine is coming of age. It’s increasingly easy to collect relevant “big data” from genomics to clinics. However, the interpretation of “big data” and translation into down-stream testable experimental hypotheses and patient-beneficial clinical applications or therapeutics remain difficult. This book demonstrates how to leverage and integrate computational & systems biology analysis of cancer genomics data and genome-wide functional genomics screens to identify novel driver-type therapeutic targets as well as predictive biomarkers to overcome drug-resistance and to treat aggressive human cancers. Specifically the author developed network-based systems biology framework to infer disease drivers from large volumes of cancer genomics data and sophisticated statistical algorithms to deconvolute and analyze noisy high-throughput microarray or NGS-based functional genomics screening data. Two of the discoveries from this book have successfully launched two clinical trials and one biomarker patent for specific subtypes of breast cancer.

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Présentation de l'éditeur

Data-driven personalized or precision medicine is coming of age. It’s increasingly easy to collect relevant “big data” from genomics to clinics. However, the interpretation of “big data” and translation into down-stream testable experimental hypotheses and patient-beneficial clinical applications or therapeutics remain difficult. This book demonstrates how to leverage and integrate computational & systems biology analysis of cancer genomics data and genome-wide functional genomics screens to identify novel driver-type therapeutic targets as well as predictive biomarkers to overcome drug-resistance and to treat aggressive human cancers. Specifically the author developed network-based systems biology framework to infer disease drivers from large volumes of cancer genomics data and sophisticated statistical algorithms to deconvolute and analyze noisy high-throughput microarray or NGS-based functional genomics screening data. Two of the discoveries from this book have successfully launched two clinical trials and one biomarker patent for specific subtypes of breast cancer.

Biographie de l'auteur

Jiyang Yu, PhD: did his PhD in Biomedical Informatics at Columbia University. Currently work as a Senior Scientist at Department of Precision Medicine, Pfizer Oncology. Research fields include computational & systems biology, bioinformatics, functional genomics, translational oncology and precision medicine.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2015
Langue
anglais
ISBN 10 
3659806439
ISBN 13 
9783659806438
Reliure
Broché
Nombre de pages
688
Coordonnées du fabricant
non disponible
Personne responsable
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