The Generalized Relative Pairs IBD Distribution:: Its Use in the Detection of Linkage - Couverture souple

Zou, Quan

 
9783659818486: The Generalized Relative Pairs IBD Distribution:: Its Use in the Detection of Linkage
Couverture souple
ISBN 10 : 3659818488 ISBN 13 : 9783659818486
Editeur : LAP LAMBERT Academic Publishing, 2016

Synopsis

Quan Zou introduces a novel approach to derive the distribution of disease affectional status given alleles identical by descent (IBD) sharing through ITO method for both dichotomous trait and quantitative trait locus (QTL). The approach tremendously simplifies the calculation of the affectional status distribution compared to the conventional method which requires the parental mating information. This distribution is shown to be independent of relative relationship and be employed to develop the marker IBD distributions, based on which, three linkage tests: the proportion, the mean test, and the LOD score test are proposed. Monte Carlo simulation studies have been conducted in order to evaluate the performance of the tests for different relative relationships. Finally, the distribution of disease affectional status is extended to the two-locus model: Quan Zou demonstrates that the ITO matrices at the two loci are decomposed under independence assumption, so that the affectional status distribution given IBD sharing at two loci can be determined through each contributing locus.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2016
Langue
anglais
ISBN 10 
3659818488
ISBN 13 
9783659818486
Reliure
Broché
Nombre de pages
104
Coordonnées du fabricant
non disponible
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