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Immune complexes: Composition and Possible Role in Pathogenesis of Severe Plasmodium falciparum Malaria - Couverture souple

Mibei, Erick K.

 
9783659839009: Immune complexes: Composition and Possible Role in Pathogenesis of Severe Plasmodium falciparum Malaria
Couverture souple
ISBN 10 : 3659839000 ISBN 13 : 9783659839009
Editeur : Scholars' Press, 2016

Synopsis

Plasmodium falciparum infection can lead to deadly complications such as severe malaria-associated anaemia (SMA) and cerebral malaria (CM). The exact mechanisms underlying pathogenesis of these severe forms of malaria are not fully understood yet they are associated with a lot of morbidity and mortality. Studies have shown a link between severe P. falciparum malaria and levels of circulating immune complexes (CIC) but the exact role that these CICs play in the pathogenesis of severe P. falciparum malaria is still unclear. This book therefore analyses the qualitative differences in antibody classes/subclasses in serum immune complexes (IC) between children with severe P. falciparum malaria and those with uncomplicated malaria and suggests the predictors of severe malaria. It also profiles the predominant P. falciparum antigens that contribute to IC formation in these groups. Based on the analysis it is therefore suggested that although SMA and CM are characterized by high levels of ICs, the antibody make up of these immune complexes as well as the role that they play in each may be distinct.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Plasmodium falciparum infection can lead to deadly complications such as severe malaria-associated anaemia (SMA) and cerebral malaria (CM). The exact mechanisms underlying pathogenesis of these severe forms of malaria are not fully understood yet they are associated with a lot of morbidity and mortality. Studies have shown a link between severe P. falciparum malaria and levels of circulating immune complexes (CIC) but the exact role that these CICs play in the pathogenesis of severe P. falciparum malaria is still unclear. This book therefore analyses the qualitative differences in antibody classes/subclasses in serum immune complexes (IC) between children with severe P. falciparum malaria and those with uncomplicated malaria and suggests the predictors of severe malaria. It also profiles the predominant P. falciparum antigens that contribute to IC formation in these groups. Based on the analysis it is therefore suggested that although SMA and CM are characterized by high levels of ICs, the antibody make up of these immune complexes as well as the role that they play in each may be distinct.

Biographie de l'auteur

Erick K Mibei, PhD: Studied Immunology at the School of Health Sciences, Kenyatta University. A career researcher and a University Don Currently a Director of Kapkatet Campus of Health Sciences, University of Kabianga, Kericho Kenya.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Scholars' Press
Date d'édition
2016
Langue
anglais
ISBN 10 
3659839000
ISBN 13 
9783659839009
Reliure
Broché
Nombre de pages
116
Coordonnées du fabricant
non disponible
Personne responsable
non disponible