Exploration of interface between graphene sheets and thrombus biology - Couverture souple

Singh, Sunil Kumar; Dash, Debabrata

Couverture souple

ISBN 10 : 3659890685 ISBN 13 : 9783659890680

Editeur : LAP LAMBERT Academic Publishing, 2016

Synopsis

Graphene, a two dimensional carbon-based nanomaterial, have attracted great research interest and are of paramount importance in numerous fields including biomedical areas. With rapid surge in research and development activities on carbon nanomaterials, risks associated with them are reasons for serious concern among scientific community. Any material injected intravenously is bound to encounter and possibly interact with blood cells, particularly platelets which are known to be highly responsive and RBCs, cells present in abundance in blood, much before the nanomaterial reaches target tissues. We evaluated the effect of graphene oxide (GO) on platelet activity and found GO can potentially activate platelets. GO-induced platelet activation could be attributed to release of intracellular free calcium from cytosolic stores and activation of non-receptor protein tyrosine kinases of Src family in platelets. Contrasting the observation with GO,amine modified graphene (G-NH2) not shown any stimulatory action towards platelets. Thus, G-NH2 can be a safer alternative to GO, with potential biomedical applications in areas like imaging, sensing, drug delivery as well as photothermal therapy.

A propos du livre

À propos de l?auteur

Dr.Singh did Masters and PhD degree in Biotechnology from BHU,India and is engaged in forefront research in Nanobiotechnology at MNNIT Allahabad, India. His research credentials are globally acknowledged and is also a recipient of prestigious INSA Medal for Young Scientist and NASI-Young Scientist Platinum Jubilee Award for the year 2014 and 2015.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2016
• Langue: anglais
• ISBN 10: 3659890685
• ISBN 13: 9783659890680
• Reliure: Broché
• Nombre de pages: 116
• Coordonnées du fabricant: non disponible
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