Articles liés à Streblus asper: Extraction, HPTLC Profile and Anticonvulsant...

Streblus asper: Extraction, HPTLC Profile and Anticonvulsant Activity - Couverture souple

Verma, Vandana; Tripathi, Avinash C.; Saraf, Shailendra K.

 
9783659915017: Streblus asper: Extraction, HPTLC Profile and Anticonvulsant Activity
Couverture souple
ISBN 10 : 3659915017 ISBN 13 : 9783659915017
Editeur : LAP LAMBERT Academic Publishing, 2016

Synopsis

A successful attempt to isolate and characterize the anticonvulsant principle, in particular from the stem bark S. asper, was pursued. The study also validates the ethno-pharmacological potential of S. asper in the treatment of neurological disorders, such as epilepsy and depression. Although, it is evident that S. asper contains several important bioactive compounds, most of the compounds have not been properly evaluated for their biological activities. Hence, isolation of some pure phytopharmaceuticals is important as these can be used as lead molecules or pharmacophores, for synthesizing novel agents having good therapeutic activity. The results obtained from the study reveal a definite role of S. asper crude extract, different fractions and the isolated compound in suppressing seizures, with a noticeable effect in the depressive behavior of the tested mice. It is also clear from the study that per cent inhibition of seizures at variable doses of betulin vary significantly. The acceptable potency and lack of acute neurotoxicity promise the development of some potential neuropharmacological agents, of natural origin from S. asper.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

A successful attempt to isolate and characterize the anticonvulsant principle, in particular from the stem bark S. asper, was pursued. The study also validates the ethno-pharmacological potential of S. asper in the treatment of neurological disorders, such as epilepsy and depression. Although, it is evident that S. asper contains several important bioactive compounds, most of the compounds have not been properly evaluated for their biological activities. Hence, isolation of some pure phytopharmaceuticals is important as these can be used as lead molecules or pharmacophores, for synthesizing novel agents having good therapeutic activity. The results obtained from the study reveal a definite role of S. asper crude extract, different fractions and the isolated compound in suppressing seizures, with a noticeable effect in the depressive behavior of the tested mice. It is also clear from the study that per cent inhibition of seizures at variable doses of betulin vary significantly. The acceptable potency and lack of acute neurotoxicity promise the development of some potential neuropharmacological agents, of natural origin from S. asper.

Biographie de l'auteur

M. Pharm. (Pharmaceutical Chemistry)from Faculty of Pharmacy, Babu Banarasi Das Northern India Institute of Technology (BBDNIIT), Lucknow.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2016
Langue
anglais
ISBN 10 
3659915017
ISBN 13 
9783659915017
Reliure
Broché
Nombre de pages
104
Coordonnées du fabricant
non disponible
Personne responsable
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