Recent concepts in host modulation therapy - Couverture souple

Vijay Thakkar, Priya; Beldar, Amol; Raghavan, Merekhna

 
9783659922954: Recent concepts in host modulation therapy
Couverture souple
ISBN 10 : 3659922951 ISBN 13 : 9783659922954
Editeur : LAP LAMBERT Academic Publishing, 2016

Synopsis

Periodontal diseases are initiated by Gram-negative tooth associated microbial biofilms that elicit a host response, with resultant osseous and soft tissue destruction. In response to endotoxins derived from periodontal pathogens, several osteoclast- related mediators target the destruction of alveolar bone and supporting connective tissues. Major drivers of this aggressive tissue destruction are matrix metalloproteinases (MMPs), cathepsins,cytokines and other osteoclast-derived enzymes. This book focuses on the downstream factors of the osteoclast responsible for the degradation of bone and soft tissues around teeth. Furthermore various therapeutic approaches that target MMPs, cytokines,cathepsins and other osteoclast-derived enzymes , such as MMP inhibitors, chemically modified tetracyclines, subantimicrobial formulations of tetracycline analogues, and various new agents such as periodontal vaccines, Probiotics, Grape seed proanthocyanidins, Cranberry fraction, omega 3 fatty acid, locally administered HMT agents are discussed. In addition, studies using other agents for the preservation of bone mass, such as bisphosphonates that inhibit osteoclast recruitment, are highlighted.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Periodontal diseases are initiated by Gram-negative tooth associated microbial biofilms that elicit a host response, with resultant osseous and soft tissue destruction. In response to endotoxins derived from periodontal pathogens, several osteoclast- related mediators target the destruction of alveolar bone and supporting connective tissues. Major drivers of this aggressive tissue destruction are matrix metalloproteinases (MMPs), cathepsins,cytokines and other osteoclast-derived enzymes. This book focuses on the downstream factors of the osteoclast responsible for the degradation of bone and soft tissues around teeth. Furthermore various therapeutic approaches that target MMPs, cytokines,cathepsins and other osteoclast-derived enzymes , such as MMP inhibitors, chemically modified tetracyclines, subantimicrobial formulations of tetracycline analogues, and various new agents such as periodontal vaccines, Probiotics, Grape seed proanthocyanidins, Cranberry fraction, omega 3 fatty acid, locally administered HMT agents are discussed. In addition, studies using other agents for the preservation of bone mass, such as bisphosphonates that inhibit osteoclast recruitment, are highlighted.

Biographie de l'auteur

Dr Amol Beldar is Reader and PG guide in Department of Periodontics and Implantology at MGV’s KBH Dental College and Hospital. He has many national and international scientific articles to his credit. Dr Priya Vijay Thakkar and Dr Merekhna Raghavan are post graduate student in department of periodontics and Implantology at MGV’s KBH Dental College.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2016
Langue
anglais
ISBN 10 
3659922951
ISBN 13 
9783659922954
Reliure
Broché
Nombre de pages
84
Coordonnées du fabricant
non disponible
Personne responsable
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