Bicistronic construct:A prophylactic weapon against paratuberculosis - Couverture souple

Goswami, P. P.; Chandrasekar, S

 
9783659924064: Bicistronic construct:A prophylactic weapon against paratuberculosis
Couverture souple
ISBN 10 : 3659924067 ISBN 13 : 9783659924064
Editeur : LAP LAMBERT Academic Publishing, 2016

Synopsis

Mycobacterium avium subsp. paratuberculosis (Map) is the causative organism of Johne’s disease or paratuberculosis, a debilitating chronic gastroenteritis of domestic and wild ruminants. At present no effective therapeutics or vaccine candidates are available and early detection along with good management practices are the only ways to control paratuberculosis. Antigens of Map have also been used for the development of DNA vaccine. Therefore, this book, provides information about potent T cell antigen family protein of Map, PE (proline-glutamic acid rich), which has been identified, expressed in prokaryotic system. The bicistronic constructs was also generated to express two potent antigens in eukaryotic system. Further the immunogenicity was also studied alone as well as with two antigens and also immunomodulatory effect of gamma interferon in murine model. Studies revealed the importance of the bicistronic construct to develop DNA vaccine against paratuberculosis infection in animals.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Mycobacterium avium subsp. paratuberculosis (Map) is the causative organism of Johne’s disease or paratuberculosis, a debilitating chronic gastroenteritis of domestic and wild ruminants. At present no effective therapeutics or vaccine candidates are available and early detection along with good management practices are the only ways to control paratuberculosis. Antigens of Map have also been used for the development of DNA vaccine. Therefore, this book, provides information about potent T cell antigen family protein of Map, PE (proline-glutamic acid rich), which has been identified, expressed in prokaryotic system. The bicistronic constructs was also generated to express two potent antigens in eukaryotic system. Further the immunogenicity was also studied alone as well as with two antigens and also immunomodulatory effect of gamma interferon in murine model. Studies revealed the importance of the bicistronic construct to develop DNA vaccine against paratuberculosis infection in animals.

Biographie de l'auteur

Dr. P. P. Goswami is Principal Scientist in the Division of Veterinary Biotechnology, ICAR-IVRI, Izatnagar, India. He has contributed in the area of gene expression leading to development of diagnostics as well as immuno prophylactics against paratuberculosis. He has guided 15 research students and published about 25 papers in last 15 years.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2016
Langue
anglais
ISBN 10 
3659924067
ISBN 13 
9783659924064
Reliure
Broché
Nombre de pages
92
Coordonnées du fabricant
non disponible
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