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Medicinal attributes of curcumin and its analogs: A comprehensive review - Couverture souple

Singh, Arshdeep; Singh, Harbinder; Sharma, Sahil

 
9783659975400: Medicinal attributes of curcumin and its analogs: A comprehensive review
Couverture souple
ISBN 10 : 3659975400 ISBN 13 : 9783659975400
Editeur : LAP LAMBERT Academic Publishing, 2016

Synopsis

From ancient times, natural products have been acting as sources of significant chemical components from which most of the metabolites are obtained. Turmeric is such a natural and popular Indian spice which is being used from centuries in herbal medicines for the treatment of variety of disorders. The yellow colour of turmeric owes to the presence of curcumin which is responsible for its therapeuctic potential and possesses significant biological properties. However its poor solubility, absorption, bioavailability and rapid metabolism in human probably limits its clinical use. These pharmacokinetic properties generally allied to its structure; therefore, researchers gave plentiful attention to improve these drawbacks associated with the native curcumin skeleton by making various structural modifications. Thus, the present assemblage includes recently reported curcumin derivatives possessing various therapeutic attributes along with the patent literature. A detailed description of the design strategies employed for the synthesis and highlights of structure activity relationship along with binding simulations of curcumin derivatives has also been presented in this compilation.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

From ancient times, natural products have been acting as sources of significant chemical components from which most of the metabolites are obtained. Turmeric is such a natural and popular Indian spice which is being used from centuries in herbal medicines for the treatment of variety of disorders. The yellow colour of turmeric owes to the presence of curcumin which is responsible for its therapeuctic potential and possesses significant biological properties. However its poor solubility, absorption, bioavailability and rapid metabolism in human probably limits its clinical use. These pharmacokinetic properties generally allied to its structure; therefore, researchers gave plentiful attention to improve these drawbacks associated with the native curcumin skeleton by making various structural modifications. Thus, the present assemblage includes recently reported curcumin derivatives possessing various therapeutic attributes along with the patent literature. A detailed description of the design strategies employed for the synthesis and highlights of structure activity relationship along with binding simulations of curcumin derivatives has also been presented in this compilation.

Biographie de l'auteur

Arshdeep Singh has completed his Bachelor of Pharmacy and Master of Pharmacy (Medicinal Chemistry) from the Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India. Presently, he is working as an Assistant Professor in the Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2016
Langue
anglais
ISBN 10 
3659975400
ISBN 13 
9783659975400
Reliure
Broché
Nombre de pages
88
Coordonnées du fabricant
non disponible
Personne responsable
non disponible