Synopsis
The natural history of Alzheimer's Disease: minding the gaps in understanding the mechanisms of neurodegeneration.-Pathological mechanisms in Huntingdon's Disease and other polyglutamine expansion diseases.-Prion protein biogenesis: implications for neurodegeneration.-The value of transgenic models for the study of neurodegenerative diseases.-Pathogenesis and mechanisms of cerebral amyloidosis in APP transgenic mice.-The next step in Notch processing and its relevance to amyloid precursor protein.-The putative role of presenilins in the transmembrance domain cleavage of amyloid precursor protein and other integral membrane proteins.-ApoE receptor in the brain: novel signaling pathways with potential relevance for Alzheimer's Disease.-Homeoprotein intercellular transport: mechanisms,significance and applications.-And other contributions
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