Neuroinflammation in Stroke - Couverture souple

9783662054284: Neuroinflammation in Stroke

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ISBN 10 : 3662054280 ISBN 13 : 9783662054284

Editeur : Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2014

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Stroke is a major cause of death and disability in industrialized countries. To date, the medical need of efficient therapy for this de- vastating cerebrovascular disorder remains unmet. During the last decades, the development of pharmacological stroke therapies was aimed at improving patient outcome by restoration of cerebral blood flow or protection from acute neuronal cell death. Almost all of The participants of the workshop VI Preface these appraaches targeted the very early events after vascular occIu- sion. However, primarily for logistical reasons, only a small portion of strakes can be treated within 6-10 h after the insult. In recent years it has been recognized that strake pathophysiology is a dynamic pracess, and that delayed pracesses, which occur dur- ing the days and weeks following arterial occIusion, may lead to further deterioration or to impairment of recovery and rehabilitation in subacute and chranic stages. Evidence is accumulating that neu- rainflammation is a major player in these delayed pathophysiologi- cal pracesses. While some components of neurainflammation such as removal of cell debris and release of traphic factors may support recovery pracesses, others such as the generation of free radicals and other cytotoxic mediators are deleterious for brain tissue after isch- emia. Thus, neurainflammation after strake can be considered a dou- ble-edged sword, having potentially both detrimental and beneficial effects. As in other inflammatory reactions in the body, the cellular and humoral interactions are highly complex in the setting of neu- rainflammation.

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�diteur: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Date d'�dition: 2014
Langue: anglais
ISBN 10: 3662054280
ISBN 13: 9783662054284
Reliure: Broch�
Nombre de pages: 236
�diteur: Dirnagl Ulrich, Elger Bernd
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Neuroinflammation in Stroke (Ernst Schering Foundation Symposium Proceedings, 47)

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ISBN 10 : 3662054280 ISBN 13 : 9783662054284

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Neuroinflammation in Stroke

Bernd Elger

Edit� par Springer Berlin Heidelberg Apr 2014, 2014

ISBN 10 : 3662054280 ISBN 13 : 9783662054284

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Stroke is a major cause of death and disability in industrialized countries. To date, the medical need of efficient therapy for this de vastating cerebrovascular disorder remains unmet. During the last decades, the development of pharmacological stroke therapies was aimed at improving patient outcome by restoration of cerebral blood flow or protection from acute neuronal cell death. Almost all of The participants of the workshop VI Preface these appraaches targeted the very early events after vascular occIu sion. However, primarily for logistical reasons, only a small portion of strakes can be treated within 6-10 h after the insult. In recent years it has been recognized that strake pathophysiology is a dynamic pracess, and that delayed pracesses, which occur dur ing the days and weeks following arterial occIusion, may lead to further deterioration or to impairment of recovery and rehabilitation in subacute and chranic stages. Evidence is accumulating that neu rainflammation is a major player in these delayed pathophysiologi cal pracesses. While some components of neurainflammation such as removal of cell debris and release of traphic factors may support recovery pracesses, others such as the generation of free radicals and other cytotoxic mediators are deleterious for brain tissue after isch emia. Thus, neurainflammation after strake can be considered a dou ble-edged sword, having potentially both detrimental and beneficial effects. As in other inflammatory reactions in the body, the cellular and humoral interactions are highly complex in the setting of neu rainflammation. 240 pp. Englisch. N� de r�f. du vendeur 9783662054284

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Neuroinflammation in Stroke (Ernst Schering Foundation Symposium Proceedings, 47)

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ISBN 10 : 3662054280 ISBN 13 : 9783662054284

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Neuroinflammation in Stroke

Ulrich Dirnagl

Edit� par Springer, Berlin, Springer, 2014

ISBN 10 : 3662054280 ISBN 13 : 9783662054284

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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Stroke is a major cause of death and disability in industrialized countries. To date, the medical need of efficient therapy for this de vastating cerebrovascular disorder remains unmet. During the last decades, the development of pharmacological stroke therapies was aimed at improving patient outcome by restoration of cerebral blood flow or protection from acute neuronal cell death. Almost all of The participants of the workshop VI Preface these appraaches targeted the very early events after vascular occIu sion. However, primarily for logistical reasons, only a small portion of strakes can be treated within 6-10 h after the insult. In recent years it has been recognized that strake pathophysiology is a dynamic pracess, and that delayed pracesses, which occur dur ing the days and weeks following arterial occIusion, may lead to further deterioration or to impairment of recovery and rehabilitation in subacute and chranic stages. Evidence is accumulating that neu rainflammation is a major player in these delayed pathophysiologi cal pracesses. While some components of neurainflammation such as removal of cell debris and release of traphic factors may support recovery pracesses, others such as the generation of free radicals and other cytotoxic mediators are deleterious for brain tissue after isch emia. Thus, neurainflammation after strake can be considered a dou ble-edged sword, having potentially both detrimental and beneficial effects. As in other inflammatory reactions in the body, the cellular and humoral interactions are highly complex in the setting of neu rainflammation. N� de r�f. du vendeur 9783662054284

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Neuroinflammation in Stroke

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ISBN 10 : 3662054280 ISBN 13 : 9783662054284

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Etat : New. pp. 240. N� de r�f. du vendeur 26128187531

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Neuroinflammation in Stroke

Dirnagl, Ulrich|Elger, Bernd

Edit� par Springer Berlin Heidelberg, 2014

ISBN 10 : 3662054280 ISBN 13 : 9783662054284

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Etat : New. G.A. Rosenberg, Sh. Mun-Bryce: Matrix Metalloproteinases in Neuroinflammation and Cerebral Ischemia H. Wolburg et al: Involvement of Tight Junctions During Transendothelial Migration of Mononuclear Cells in Experimental Autoimmune Encephalomyelitis St. Al. N� de r�f. du vendeur 5221539

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