The Human T-Cell Receptor Repertoire and Transplantation - Couverture souple

Couverture souple

ISBN 10 : 3662224968 ISBN 13 : 9783662224960

Editeur : Springer, 2013

Synopsis

these analyses it became clear that the MHC class I molecule com- prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec- tron-dense material in the groove. This material was subsequently iden- 568 10 tified as a linear peptide of 8-10 amino acids long. - -- High resolu- tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep- tion of the DR a-chain, all other MHC class II a and 13 chains are poly- morphic.

Détails de l'édition

• Éditeur: Springer
• Date d'édition: 2013
• Langue: anglais
• ISBN 10: 3662224968
• ISBN 13: 9783662224960
• Reliure: Broché
• Nombre de pages: 188
• Éditeur: Elsen Peter Van Den
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne