Laron Syndrome: From Man to Mouse: Lessons from Clinical and Experimental Experience - Couverture souple

Couverture souple

ISBN 10 : 3662501716 ISBN 13 : 9783662501719

Editeur : Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2016

Synopsis

First book covering this interesting topic, written by Zvi Laron who first described and reported the condition in 1966 (this syndrome is named after him) Describes the comprehensive pathophysiology of IGF-I deficiency and gives valuable advice for the IGF-I treatment Compares IGF-I and GH deficiency and illustrates the effects of the treatment, e.g. metabolic effects, adipose tissue alterations and the effects on aging Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions. Content Level Professional/practitioner Keywords Effects on Aging - GH inactivity - GH insensitivity - GH receptor gene disruption - GH resistance - IGF-treatment - Laron Syndrome - Metabolic Effects Related subjects Human Genetics - Human Physiology - Internal Medicine - Molecular Medicine - Pediatrics

A propos du livre

Présentation de l'éditeur

Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.

Détails de l'édition

• Éditeur: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• Date d'édition: 2016
• Langue: anglais
• ISBN 10: 3662501716
• ISBN 13: 9783662501719
• Reliure: Broché
• Nombre de pages: 545
• Éditeur: Laron Zvi, Kopchick J.
• Coordonnées du fabricant: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3,69115 Heidelberg, Germany; Heidelberg; 69115; Allemagne