Synopsis
This book is divided into 3 parts. Part 1 summarizes the pro-angiogenic factors and anti-angiogenic molecules including their mechanism of action. Part 2 summarizes the preclinical data arising from the experimental evaluation of anti-angiogenic and pro-angiogenic compounds in cell culture and animal models. This will help to elucidate their mechanism of action in different biologic systems and cancer types. Based on this knowledge, clinicians will be able to incorporate these new drugs into the scenario of established therapies and finally improve curative approaches. Part 3 summarizes experimental and clinical studies of combined therapy with anti-angiogenic agents and highlights the challenges related to the appropriate strategies for selection of the patients, study design, and choice of proper end points for preclinical and clinical studies using these agents.
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Tumor Angiogenesis
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Springer Berlin Heidelberg Aug 2016, 2016
ISBN 10 : 3662517981
ISBN 13 : 9783662517987
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Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Tumor angiogenesis is one of the most prominent mechanisms driving tumor development and progression. This book is written by internationally renowned experts. Part 1 describes the basic mechanisms. Tumor-angiogenic signaling pathways are presented as new potential targets for anti-angiogenic therapy. Part 2 reviews the efforts made to validate new targets and to show efficacy in animals. Part 3 is devoted to the clinical development of the novel anti-angiogenic drugs and their use in clinical practice. 864 pp. Englisch. N° de réf. du vendeur 9783662517987
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Tumor Angiogenesis | Basic Mechanisms and Cancer Therapy
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Taschenbuch. Etat : Neu. Tumor Angiogenesis | Basic Mechanisms and Cancer Therapy | Dieter Marmé (u. a.) | Taschenbuch | xviii | Englisch | 2016 | Springer | EAN 9783662517987 | Verantwortliche Person für die EU: Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. N° de réf. du vendeur 109582736
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Tumor Angiogenesis : Basic Mechanisms and Cancer Therapy
Edité par
Springer, Berlin, Springer, 2016
ISBN 10 : 3662517981
ISBN 13 : 9783662517987
Neuf
Taschenbuch
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Preface Tumor development and progression occur as a result of cumulative acquisition of genetic alterations affecting oncogenes and tumor suppressor genes. As a consequence of these alterations the arising tumor gains some fatal properties such as increased cell proliferation and decreased apoptosis, resulting in a net accumulation of tra- formed cells. Once a critical volume is achieved, lack of oxygen and nutrients limits further growth. To overcome this obstacle, the tumor cells initiate a program focused on the formation of new blood vessels within the host tissue. This process is termed tumor angiogenesis and contributes to the progression of most solid tumors and the formation of metastases. Since its discovery more than 30 years ago by Dr. Judah Folkman, tumor angiog- esis has been proposed as an ideal target for novel tumor therapies. Today the first anti-angiogenic compounds are available for the treatment of patients but their s- cess in the clinic is rather limited when given as monotherapies. This is in contrast to many preclinical results which revealed a much higher efficacy of these therapeutics in appropriate animal models. The reasons for this discrepancy are manifold, one being the existence of more than one angiogenic signaling system capable of driving tumor angiogenesis. Therefore it is no surprise that the inhibition of just one system is not sufficient to block the formation of new blood vessels in patients. N° de réf. du vendeur 9783662517987
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