Articles liés à Fluorescence in Situ Hybridization: Application Guide

Fluorescence in Situ Hybridization: Application Guide - Couverture rigide

 
9783662529577: Fluorescence in Situ Hybridization: Application Guide
Couverture rigide
ISBN 10 : 3662529572 ISBN 13 : 9783662529577
Editeur : Springer-Verlag Berlin and Heidelberg GmbH & Co. K, 2016

Synopsis

This manual offers detailed protocols for fluorescence in situ hybridization (FISH) and comparative genomic hybridization approaches, which have been successfully used to study various aspects of genomic behavior and alterations. Methods using different probe and cell types, tissues and organisms, such as mammalians, fish, amphibians (including lampbrush-chromosomes), insects, plants and microorganisms are described in 57 chapters. In addition to multicolor FISH procedures and special applications such as the characterization of marker chromosomes, breakpoints, cryptic aberrations, nuclear architectures and epigenetic changes, as well as comparative genomic hybridization studies, this 2nd edition describes how FISH can be combined with other techniques. The latter include immunostaining, electron microscopy, single cell electrophoresis and microdissection.

This well-received application guide provides essential protocols for beginning FISHers and FISH experts alike working inthe fields of human genetics, microbiology, animal and plant sciences.



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À propos de l'auteur

Dr. Thomas Liehr, a biologist (diploma, PhD and postdoctoral degree in human genetics), has been working in molecular cytogenetics since 1991. He has been head of the molecular cytogenetic group at the Institute of Human Genetics, Jena, Germany since 1998; before he was a PhD fellow of the Herbert Quandt Stiftung der VARTA-AG at the Institute of Human Genetics, Erlangen, Germany. Working intensively in diagnostics, since 2002 he has been a 'specialist in human genetics diagnostics' (FHG = Fachhumangenetiker), a title awarded by the German Society of Human Genetics (GfH), and a European registered Clinical Laboratory Geneticist (ErCLG) since 2015. Dr. Liehr's research fields include clinical genetics, leukemia cytogenetics and the (3D) structures of the interphase and the human chromosomes, as well as breakpoint characterization. The results of his research have been published in 5 books, >50 book chapters, >550 peer-reviewed papers, and 800 abstracts. His particular expertiseis molecular cytogenetics including chromosomal heteromorphisms, small supernumerary marker chromosomes (sSMC) and uniparental disomy, fields for which he has collected all available literature and made it freely available on the Internet. Further, Dr. Liehr has multiple longstanding international collaborations with many scientists around the world including researchers in e.g. Armenia, Croatia, India, Morocco, Russia, Serbia, Thailand, and Brazil.



Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Date d'édition
2016
Langue
anglais
ISBN 10 
3662529572
ISBN 13 
9783662529577
Reliure
Relié
Numéro d'édition
2
Nombre de pages
619
Éditeur
Liehr Thomas
Coordonnées du fabricant
non disponible
Personne responsable
CMN Printpool Inh. Mathis Neumann
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