A toolkit to study nuclear transport pathways: nanobody-mediated inhibition of importin ¿-related nuclear transport receptors (NTRs) - Couverture souple
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A toolkit to study nuclear transport pathways: nanobody-mediated inhibition of importin ¿-related nuclear transport receptors (NTRs)
Edité par
Cuvillier, Cuvillier Aug 2023, 2023
ISBN 10 : 3736978472
ISBN 13 : 9783736978478
Neuf
Taschenbuch
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 136 pp. Englisch. N° de réf. du vendeur 9783736978478
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EUR 40,90
Expédition à EUR 23
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A toolkit to study nuclear transport pathways: nanobody-mediated inhibition of importin ¿-related nuclear transport receptors (NTRs)
Edité par
Cuvillier, Cuvillier Aug 2023, 2023
ISBN 10 : 3736978472
ISBN 13 : 9783736978478
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Eukaryotic cells are divided into a nuclear and a cytoplasmic compartment. This separates transcription from translation and makes gene expression dependent on nucleocytoplasmic transport. The members of the importin ß superfamily function as shuttling nuclear transport receptors (NTRs) that recognize and actively transport cargoes through nuclear pores. An estimated 5 000 to 10 000 different human proteins are subject to active nuclear transport. Numerous cargo/NTR pairs have been identified, however, we are still far from a complete understanding as it has been very challenging to setup a systematic in vivo analysis that integrates the impact of all transport pathways.In this study, we obtained anti-NTR nanobodies against TRN1, Xpo4, Xpo7, and CAS. Our aim was to identify nanobodies, and prepare nanobody fusions, that impede nuclear pore-passage of the targeted NTR and thus, interrupt a given transport cycle. These nanobody fusions were observed to inhibit the partition of NTR/cargo complexes into a reconstituted FG phase. We also observed that the nanobodies and nanobody fusions inhibit NTR transport in permeabilized cells.Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 136 pp. Englisch. N° de réf. du vendeur 9783736978478
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A toolkit to study nuclear transport pathways: nanobody-mediated inhibition of importin ¿-related nuclear transport receptors (NTRs)
impression à la demandeVendeur : AHA-BUCH GmbH, Einbeck, Allemagne
Évaluation du vendeur 5 sur 5 étoiles
Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Eukaryotic cells are divided into a nuclear and a cytoplasmic compartment. This separates transcription from translation and makes gene expression dependent on nucleocytoplasmic transport. The members of the importin ß superfamily function as shuttling nuclear transport receptors (NTRs) that recognize and actively transport cargoes through nuclear pores. An estimated 5 000 to 10 000 different human proteins are subject to active nuclear transport. Numerous cargo/NTR pairs have been identified, however, we are still far from a complete understanding as it has been very challenging to setup a systematic in vivo analysis that integrates the impact of all transport pathways.In this study, we obtained anti-NTR nanobodies against TRN1, Xpo4, Xpo7, and CAS. Our aim was to identify nanobodies, and prepare nanobody fusions, that impede nuclear pore-passage of the targeted NTR and thus, interrupt a given transport cycle. These nanobody fusions were observed to inhibit the partition of NTR/cargo complexes into a reconstituted FG phase. We also observed that the nanobodies and nanobody fusions inhibit NTR transport in permeabilized cells. N° de réf. du vendeur 9783736978478
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Expédition à EUR 60,94
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Expédition depuis Allemagne vers Etats-Unis
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A toolkit to study nuclear transport pathways: nanobody-mediated inhibition of importin ¿-related nuclear transport receptors (NTRs)
impression à la demandeVendeur : preigu, Osnabrück, Allemagne
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Taschenbuch. Etat : Neu. A toolkit to study nuclear transport pathways: nanobody-mediated inhibition of importin ¿-related nuclear transport receptors (NTRs) | Dilantha Perera | Taschenbuch | Englisch | 2023 | Cuvillier | EAN 9783736978478 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu Print on Demand. N° de réf. du vendeur 133717755
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Expédition à EUR 70
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Expédition depuis Allemagne vers Etats-Unis
Quantité disponible : 5 disponible(s)