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A multi-omics view on the pathogen Yersinia pseudotuberculosis ¿ bridging metabolism and virulence
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Yersinia pseudotuberculosis is a human pathogen that causes acute intestinal and systemic diseases. This study investigated the link between pathogenic traits and the metabolic core machinery of Y. pseudotuberculosis using a systems biology approach: the integration of gene expression profiles with metabolic pathway fluxes in the wild type and virulence regulator mutants. The absence of specific virulence regulators particularly perturbed fluxes and gene expression of pyruvate metabolism and tricarboxylic acid cycle, suggesting an involvement of this metabolic node in the virulence management system. Mutants, genetically perturbed in regulators of this metabolic branch point and one of its central enzymes, showed a significant reduction of virulence in an oral mouse infection model. This revealed the pyruvate-TCA cycle node as a focal point for controlling host colonization. Flux rerouting was also identified as response to applied antibiotic therapies. The examination of Yersiniäs fine-tuned adaptation was expanded to temperature, an important infection parameter, using a continuous culture with advanced temperature control to mimic the infection process. The virulence regulator RovA, known to respond to temperature and to control metabolic, stress, and virulence genes, was quantified by Western blot analysis and fluorescence-activated cell sorting. RovA showed a bistable behavior that generally maximizes survival by heterogeneity. 132 pp. Englisch. N° de réf. du vendeur 9783736990395
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A multi-omics view on the pathogen Yersinia pseudotuberculosis - bridging metabolism and virulence
Edité par
Cuvillier Verlag, 2015
ISBN 10 : 3736990391
ISBN 13 : 9783736990395
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Couverture souple
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. KlappentextrnrnYersinia pseudotuberculosis is a human pathogen that causes acute intestinal and systemic diseases. This study investigated the link between pathogenic traits and the metabolic core machinery of Y. pseudotuberculosis using a syste. N° de réf. du vendeur 116769318
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A multi-omics view on the pathogen Yersinia pseudotuberculosis - bridging metabolism and virulence
Edité par
Cuvillier, Cuvillier Aug 2015, 2015
ISBN 10 : 3736990391
ISBN 13 : 9783736990395
Neuf
Taschenbuch
Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Yersinia pseudotuberculosis is a human pathogen that causes acute intestinal and systemic diseases. This study investigated the link between pathogenic traits and the metabolic core machinery of Y. pseudotuberculosis using a systems biology approach: the integration of gene expression profiles with metabolic pathway fluxes in the wild type and virulence regulator mutants. The absence of specific virulence regulators particularly perturbed fluxes and gene expression of pyruvate metabolism and tricarboxylic acid cycle, suggesting an involvement of this metabolic node in the virulence management system. Mutants, genetically perturbed in regulators of this metabolic branch point and one of its central enzymes, showed a significant reduction of virulence in an oral mouse infection model. This revealed the pyruvate-TCA cycle node as a focal point for controlling host colonization. Flux rerouting was also identified as response to applied antibiotic therapies. The examination of Yersinia's fine-tuned adaptation was expanded to temperature, an important infection parameter, using a continuous culture with advanced temperature control to mimic the infection process. The virulence regulator RovA, known to respond to temperature and to control metabolic, stress, and virulence genes, was quantified by Western blot analysis and fluorescence-activated cell sorting. RovA showed a bistable behavior that generally maximizes survival by heterogeneity.Cuvillier Verlag, Nonnenstieg 8, 37075 Göttingen 132 pp. Englisch. N° de réf. du vendeur 9783736990395
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A multi-omics view on the pathogen Yersinia pseudotuberculosis ¿ bridging metabolism and virulence
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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Yersinia pseudotuberculosis is a human pathogen that causes acute intestinal and systemic diseases. This study investigated the link between pathogenic traits and the metabolic core machinery of Y. pseudotuberculosis using a systems biology approach: the integration of gene expression profiles with metabolic pathway fluxes in the wild type and virulence regulator mutants. The absence of specific virulence regulators particularly perturbed fluxes and gene expression of pyruvate metabolism and tricarboxylic acid cycle, suggesting an involvement of this metabolic node in the virulence management system. Mutants, genetically perturbed in regulators of this metabolic branch point and one of its central enzymes, showed a significant reduction of virulence in an oral mouse infection model. This revealed the pyruvate-TCA cycle node as a focal point for controlling host colonization. Flux rerouting was also identified as response to applied antibiotic therapies. The examination of Yersiniäs fine-tuned adaptation was expanded to temperature, an important infection parameter, using a continuous culture with advanced temperature control to mimic the infection process. The virulence regulator RovA, known to respond to temperature and to control metabolic, stress, and virulence genes, was quantified by Western blot analysis and fluorescence-activated cell sorting. RovA showed a bistable behavior that generally maximizes survival by heterogeneity. N° de réf. du vendeur 9783736990395
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A multi-omics view on the pathogen Yersinia pseudotuberculosis - bridging metabolism and virulence
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Taschenbuch. Etat : Neu. A multi-omics view on the pathogen Yersinia pseudotuberculosis - bridging metabolism and virulence | René Bücker | Taschenbuch | Hochschulschriften - Institut für Systembiotechnologie, Universität des Saarlandes 2 | 132 S. | Englisch | 2015 | Cuvillier | EAN 9783736990395 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu Print on Demand. N° de réf. du vendeur 104021110
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