Equine Metabolic Syndrome. (Patho-)physiological variations in insulin sensitivity, glucose homeostasis and lipid metabolism in lean and obese horses - Couverture souple

Warnken, Tobias

Couverture souple

ISBN 10 : 3736998066 ISBN 13 : 9783736998063

Editeur : Cuvillier, 2018

Synopsis

Variations in insulin regulation reflect either as tissue insulin resistance or insulin dysregulation result in moderate to severe hyperinsulinemia in horses and ponies suffering from the Equine Metabolic Syndrome (EMS). Several pathomechanisms provoking equine insulin resistance have been suggested, but insulin signaling in healthy horses has not been studied in detail so far. Thus the objective of this PhD project was to investigate equine insulin sensitivity, glucose homeostasis and lipid metabolism by combining examinations of insulin signaling on a protein level in different main metabolic tissues and analyses of dynamic hormone and metabolite changes during acute stimulations by either oral glucose application or IV insulin and glucose injection. Furthermore, systemic markers of insulin resistance were analyzed by an innovative targeted metabolomics approach to provide better understanding of potential pathomechanisms involved in impaired insulin regulation in horses. In conclusion, equine-specific insulin signaling, the marginal relationship of insulin sensitivity to obesity and strong associations of high plasma insulin concentration to cellular oxidative stress depicted not only a special physiological condition but also indicate novel pathophysiological conditions underlying EMS.

Détails de l'édition

• Éditeur: Cuvillier
• Date d'édition: 2018
• Langue: anglais
• ISBN 10: 3736998066
• ISBN 13: 9783736998063
• Reliure: Broché
• Nombre de pages: 118
• Coordonnées du fabricant: info@cuvillier.de; info@cuvillier.de; ; Nonnenstieg 8; Göttingen; 37075; Allemagne