High-throughput screening and evaluation of combinatorial cell penetrating peptoid libraries to identify organelle- and organ-specific drug delivery molecules - Couverture souple

Wehl, Ilona Diana Majella

 
9783736999961: High-throughput screening and evaluation of combinatorial cell penetrating peptoid libraries to identify organelle- and organ-specific drug delivery molecules
Couverture souple
ISBN 10 : 3736999968 ISBN 13 : 9783736999961
Editeur : Cuvillier, 2019

Synopsis

Drug delivery systems can increase the pharmacokinetic and pharmacodynamic properties of various therapeutic agents. These systems can ensure a controlled release, improve the specificity of drugs to the target tissue, and therefore decrease side effects to the healthy surrounding tissue. In this work cell penetrating peptoids, which mimic the structure of peptides but exhibit increased stability, were investigated as organelle- and organ-specific carrier molecules. Several fluorescently labelled peptoid libraries, differing for example in length and side-chain composition, were synthesized and investigated with high-throughput screenings in different cell lines. The focus was on the elucidation of structure-function relationships for cellular uptake, intracellular localization and cytotoxicity. Furthermore, the organ targeting of the peptoids was analysed in in vivo studies by using zebrafish as model organism. In addition, the influence of the fluorescent dye on the localization and uptake of the peptoids was investigated.

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Éditeur
Cuvillier
Date d'édition
2019
Langue
anglais
ISBN 10 
3736999968
ISBN 13 
9783736999961
Reliure
Broché
Nombre de pages
182
Coordonnées du fabricant
info@cuvillier.de
info@cuvillier.de

Nonnenstieg 8
Göttingen
37075
Allemagne