Epithelial - Mesenchymal Interactions in Cancer - Couverture rigide

Couverture rigide

ISBN 10 : 3764351179 ISBN 13 : 9783764351175

Editeur : Birkhauser Verlag AG, 1995

Synopsis

Since the end of the 1980s, considerable progress has been made in identifying some of the molecular mechanisms through which tumour cells interact with stroma. The material contained in this volume aims to provide an overview of the field of epithelial-mesenchymal interaction.

A propos du livre

Présentation de l'éditeur

The contribution of epithelia-mesenchyme interaction to normal development (eg., tissue formation) and to neoplasia has become a subject of increasing interest to scientists because of recent progress in deciphering the molecular signals that mediate this interaction. Clearly, some of the same types of molecules (eg., growth factors and their receptors, proteolytic enzymes, cell adhesion molecules, and structural proteins of the extracellular matrix) mediate exchange of information between epithelia and mesenchyme during normal development and malignant growth. However, defects in the regulation of this exchange appear to contribute to malignancy by allowing growth promoting, invasogenic, and angiogenic factors to accumulate within the microenvironment of the tumor. For example, recent studies suggest that abnormal interactions between tumor epithelial cells and stromal mesenchymal cells contribute to the overproduction and accumulation of scatter factor (hepatocyte growth factor), an invasogenic and angiogenic cytokine, in certain types of tumor. The production and and activation of type IV collagenase, a matrix-degrading enzyme required for tumor cell invasion, appears to require intimate cooperation between tumor and stromal cells. The material contained in this volume highlights the state-of-the-art of knowledge of the molecular mechanisms by which epithelia and mesenchyme collaborate, and the abnormalities in these mechanisms that may lead to the development of cancer.

Détails de l'édition

• Éditeur: Birkhauser Verlag AG
• Date d'édition: 1995
• ISBN 10: 3764351179
• ISBN 13: 9783764351175
• Reliure: Relié
• Langue: anglais
• Nombre de pages: 350
• Éditeur: Goldberg Itzhak D., Rosen Eliot M.
• Coordonnées du fabricant: non disponible