Articles liés à Nmda Antagonists As Potential Analgesic Drugs
Synopsis
There is now considerable preclinical evidence that glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This evidence allows rational development of a new class of analgesic drugs that act as antagonists of the NMDA receptor, supported by emerging evidence with existing excitatory amino acid antagonists. L
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NMDA Antagonists as Potential Analgesic Drugs
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Birkhauser, Switzerland, 2002
ISBN 10 : 3764360119
ISBN 13 : 9783764360115
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Hardcover. Etat : Near Fine. 3764360119. Pictorial board hardcover, from closed pharmaceutical company library. Appears unread. 194 pages, index, illustrated with charts, tables and diagrams. Glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This evidence allows development of a new class of analgesic drugs that act as antagonists of the NMDA receptor, supported by emerging evidence with existing excitatory amino acid antagonists. Leading scientists in excitatory amino acid and analgesia research have compiled in this volume the most recent information on molecular biology, physiology and pharmacology of NMDA receptors, their neuroanatomical localisation within specific neural pathways involved in nociception, and experimental and clinical evidence demonstrating the potential of receptor antagonists of NMDA and other excitatory amino acids in the treatment of pain states. Contents clean, tight and bright. Book. N° de réf. du vendeur 031942
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NMDA Antagonists as Potential Analgesic Drugs
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Birkhäuser Basel, 2002
ISBN 10 : 3764360119
ISBN 13 : 9783764360115
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. There is now considerable preclinical evidence that glutamate acting via the NMDA receptor is involved in the transmission of nociceptive information and in the triggering mechanisms for hyperalgesia and allodynia. This evidence allows rational development. N° de réf. du vendeur 5279251
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NMDA Antagonists as Potential Analgesic Drugs (Progress in Inflammation Research)
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NMDA Antagonists as Potential Analgesic Drugs
Edité par
Birkhäuser Basel, 2002
ISBN 10 : 3764360119
ISBN 13 : 9783764360115
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Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Dalip J. S. Sirinathsinghii and Ray G. Hill Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK There remains a distinct medical need for new pain therapies. Therefore, it is not surprising that in recent years there has been a major research initiative in both aca demic and pharmaceutical laboratories to identify novel pain targets and to devel op novel analgesic drugs. It is clear from numerous studies that the NMDA recep tor plays a major role in the transmission ofnociceptive information and it has been a subject of extensive investigation over the last decade exploiting the advances of molecular pharmacology and molecular neuroanatomy. As a consequence there has been a rational approach by several laboratories to develop receptor subtype-spe cific NMDA antagonists in order to avoid the wide range of side-effects seen with non-selective NMDA ion channel antagonists such as ketamine. This volume brings together contributions from experts in various technological disciplines who have contributed immensely to NMDA receptor research and advanced our understanding of the subunit composition of the NMDA receptor complex, its pharmacology and distribution, its interaction with other neurochemi cal systems and the effects on behaviour of NMDA antagonists in rodent models and in the clinic. In consideration of these advances and the prospects of novel NMDA receptor antagonists in the near future for the treatment of pain, this vol ume is very timely. N° de réf. du vendeur 9783764360115
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NMDA Antagonists as Potential Analgesic Drugs
Edité par
Springer, Basel, Birkhäuser Basel Jan 2002, 2002
ISBN 10 : 3764360119
ISBN 13 : 9783764360115
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Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Dalip J. S. Sirinathsinghii and Ray G. Hill Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK There remains a distinct medical need for new pain therapies. Therefore, it is not surprising that in recent years there has been a major research initiative in both aca demic and pharmaceutical laboratories to identify novel pain targets and to devel op novel analgesic drugs. It is clear from numerous studies that the NMDA recep tor plays a major role in the transmission ofnociceptive information and it has been a subject of extensive investigation over the last decade exploiting the advances of molecular pharmacology and molecular neuroanatomy. As a consequence there has been a rational approach by several laboratories to develop receptor subtype-spe cific NMDA antagonists in order to avoid the wide range of side-effects seen with non-selective NMDA ion channel antagonists such as ketamine. This volume brings together contributions from experts in various technological disciplines who have contributed immensely to NMDA receptor research and advanced our understanding of the subunit composition of the NMDA receptor complex, its pharmacology and distribution, its interaction with other neurochemi cal systems and the effects on behaviour of NMDA antagonists in rodent models and in the clinic. In consideration of these advances and the prospects of novel NMDA receptor antagonists in the near future for the treatment of pain, this vol ume is very timely. 194 pp. Englisch. N° de réf. du vendeur 9783764360115
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Nmda Antagonists As Potential Analgesic Drugs
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NMDA Antagonists as Potential Analgesic Drugs (Progress in Inflammation Research)
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NMDA Antagonists as Potential Analgesic Drugs
Edité par
Birkhäuser Basel, Birkhäuser Basel Jan 2002, 2002
ISBN 10 : 3764360119
ISBN 13 : 9783764360115
Neuf
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Buch. Etat : Neu. Neuware -Dalip J. S. Sirinathsinghii and Ray G. Hill Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK There remains a distinct medical need for new pain therapies. Therefore, it is not surprising that in recent years there has been a major research initiative in both aca demic and pharmaceutical laboratories to identify novel pain targets and to devel op novel analgesic drugs. It is clear from numerous studies that the NMDA recep tor plays a major role in the transmission ofnociceptive information and it has been a subject of extensive investigation over the last decade exploiting the advances of molecular pharmacology and molecular neuroanatomy. As a consequence there has been a rational approach by several laboratories to develop receptor subtype-spe cific NMDA antagonists in order to avoid the wide range of side-effects seen with non-selective NMDA ion channel antagonists such as ketamine. This volume brings together contributions from experts in various technological disciplines who have contributed immensely to NMDA receptor research and advanced our understanding of the subunit composition of the NMDA receptor complex, its pharmacology and distribution, its interaction with other neurochemi cal systems and the effects on behaviour of NMDA antagonists in rodent models and in the clinic. In consideration of these advances and the prospects of novel NMDA receptor antagonists in the near future for the treatment of pain, this vol ume is very timely. 208 pp. Englisch. N° de réf. du vendeur 9783764360115
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Nmda Antagonists As Potential Analgesic Drugs
Edité par
Birkhäuser, 2002
ISBN 10 : 3764360119
ISBN 13 : 9783764360115
Ancien ou d'occasion
Couverture rigide
Vendeur : GreatBookPrices, Columbia, MD, Etats-Unis
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Etat : As New. Unread book in perfect condition. N° de réf. du vendeur 1203002
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NMDA Antagonists as Potential Analgesic Drugs
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Etat : New. pp. viii + 194. N° de réf. du vendeur 2614418828
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