An Investigation of MicroRNA Target Reulation Mechanisms Using an Integrative Approach - Couverture souple

Schmitz, Ulf

 
9783832540050: An Investigation of MicroRNA Target Reulation Mechanisms Using an Integrative Approach
Couverture souple
ISBN 10 : 3832540059 ISBN 13 : 9783832540050
Editeur : Logos Verlag Berlin GmbH, 2015

Synopsis

This work is a showcase for the integration of systems biology and bioinformatics tools, algorithms and models for deciphering biological phenomena. More specifically, it integrates (i) prediction algorithms for identifying and characterizing molecular interactions, (ii) structural modelling of molecule complexes, (iii) network analysis approaches, and (iv) mathematical modelling and simulation. Two comprehensive workflows are implemented for the analysis of collective target gene regulation by microRNAs and for the prediction of cooperating microRNA pairs and their mutual target genes. In two case studies mechanisms of fine-tuned target gene regulation are revealed for different cellular processes and the phenomenon of cooperative target regulation is identified as frequent mechanism of gene regulation in humans.

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Éditeur
Logos Verlag Berlin GmbH
Date d'édition
2015
Langue
anglais
ISBN 10 
3832540059
ISBN 13 
9783832540050
Reliure
Broché
Nombre de pages
192
Coordonnées du fabricant
non disponible
Personne responsable
non disponible