Photomodulation of Supramolecular Systems Containing Bioactive Small Molecules and Biopolymers - Couverture souple

Karcher, Johannes

Couverture souple

ISBN 10 : 3832550992 ISBN 13 : 9783832550998

Editeur : Logos Verlag Berlin GmbH, 2020

Synopsis

Molecular photoswitches can change their conformation upon irradiation with light and convert this molecular movement into macroscopic changes of sophisticated materials. By combining state-of-the-art azobenzenes with supramolecular low-molecular-weight gelators, based on cyclic dipeptides, photomodulation of hydrogels was achieved. Photochromic amino acids with structures related to the natural L-phenylalanine were an essential element. The supramolecular hydrogels are multi-responsive towards pH, ions, temperature, and, in particular, light. Hereby the gelator F2-PAP-DKP-Lys can be turned into a sol upon irradiation with green light and within this transition a drug, for example an antibiotic, was released. The further improved supergelator Cl4-PAP-DKP-Lys2 is reversibly switchable with red and violet light in the range of 0.2-0.5 % in an isotonic Ringer's solution. At a concentration of 1 %, the hydrogel consisting of Cl4-PAP-DKP-Lys2 remains stable in a boiling water bath. Thus, we envision that the enhanced stability of the supramolecular assembly of Cl4-PAP-DKP-Lys2 and orthogonal biocompatibility of F2-PAP-DKP-Lys, could enable further applications, spanning from regenerative medicine to electronic devices, besides our future vision towards photopharmacology.

Détails de l'édition

• Éditeur: Logos Verlag Berlin GmbH
• Date d'édition: 2020
• Langue: anglais
• ISBN 10: 3832550992
• ISBN 13: 9783832550998
• Reliure: Broché
• Nombre de pages: 322
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible