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Regulatory Networks of Gene Expression in Heart and Skeletal Muscle Cells: The Role of Histone Modifications and Transcription Factors in Muscle Cell Development and Maintenance - Couverture souple

Fischer, Jenny J.

 
9783836483735: Regulatory Networks of Gene Expression in Heart and Skeletal Muscle Cells: The Role of Histone Modifications and Transcription Factors in Muscle Cell Development and Maintenance
Couverture souple
ISBN 10 : 3836483734 ISBN 13 : 9783836483735
Editeur : VDM Verlag Dr. Müller, 2008

Synopsis

The development and maintenance of muscle cells is controlled by complex regulatory networks involving epigenetic marks and transcription factors. While histone modifications influence the compaction of chromatin and consequently the accessibility of DNA, transcription factors are responsible for a fine tuning of expression. In this study, modern high-throughput methods of molecular biology together with bioinformatic analyses were used to decipher the architecture of these networks. The role of activating histone modifications and their potential interactions with key cardiac transcription factors in the context of muscle development and congenital heart diseases are presented. Several hundred genes regulated by the transcription factors Gata4, Mef2a, Nkx2.5, and Srf were identified, demonstrating their essential role in the formation of cardiac structures. The findings support the existence of a complex combinatorial 'histone code' and suggest that histone modifications have further functions as signaling marks. This book is addressed to researchers in a modern molecular biology laboratory, including the fields of biology, biochemistry, bioinformatics, and medicine.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l'auteur

Jenny J. Fischer studied Chemistry at the Freie Universität Berlin. During a stay at the RIKEN Institute in Japan she investigated the properties of biodegradable polymers, resulting in her Diploma thesis. She is now a postdoctoral research fellow at the Max Planck Institute for Molecular Genetics where she also obtained her PhD in Biochemistry.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
VDM Verlag Dr. Müller
Date d'édition
2008
Langue
anglais
ISBN 10 
3836483734
ISBN 13 
9783836483735
Reliure
Broché
Nombre de pages
176
Coordonnées du fabricant
non disponible
Personne responsable
non disponible