Articles liés à Innate immune signalling: NF-kappaB activation in infections...

Innate immune signalling: NF-kappaB activation in infections with Helicobacter pylori or Legionella pneumophila - Couverture souple

Bartfeld, Sina

 
9783838110745: Innate immune signalling: NF-kappaB activation in infections with Helicobacter pylori or Legionella pneumophila
Couverture souple
ISBN 10 : 3838110749 ISBN 13 : 9783838110745
Editeur : Südwestdeutscher Verlag für Hochschulschriften, 2009

Synopsis

During infection the human body interacts intimately with the infectious pathogen. It is this interaction that determines disease outcome. Upon infection the protein NF-kappaB acts as a central signal transmitter of the innate immune system. This protein has two main functions: the activation of genes important for inflammation as well as those that secure survival of the cell. This dual role provides a mechanistic link between infections and cancer development, as seen during infection with the carcinogenic bacterium Helicobacter pylori. Bacteria that develop intracellularly, such as Legionella pneumophila, depend on the survival of the host cell and can thus benefit from NF-kappaB activation. But how is NF-kappaB activated in these infections? And how is the activation terminated? The author introduces us to NF-kappaB signalling and then analyses NF-kappaB activation during infections with H. pylori or L. pneumophila. She establishes a new test system for high-throughput screenings and identifies new cellular factors important in NF-kappaB activation and termination. The identification of these factors broadens our understanding of innate immune signalling.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

During infection the human body interacts intimately with the infectious pathogen. It is this interaction that determines disease outcome. Upon infection the protein NF-kappaB acts as a central signal transmitter of the innate immune system. This protein has two main functions: the activation of genes important for inflammation as well as those that secure survival of the cell. This dual role provides a mechanistic link between infections and cancer development, as seen during infection with the carcinogenic bacterium Helicobacter pylori. Bacteria that develop intracellularly, such as Legionella pneumophila, depend on the survival of the host cell and can thus benefit from NF-kappaB activation. But how is NF-kappaB activated in these infections? And how is the activation terminated? The author introduces us to NF-kappaB signalling and then analyses NF-kappaB activation during infections with H. pylori or L. pneumophila. She establishes a new test system for high-throughput screenings and identifies new cellular factors important in NF-kappaB activation and termination. The identification of these factors broadens our understanding of innate immune signalling.

Biographie de l'auteur

Sina Bartfeld studied biology at the universities of Hamburg,Berlin and Melbourne. She was awarded her doctorate from HumboldtUniversity Berlin in 2009. She conducted research for herdissertation at the Max Planck Institute for Infection Biology inBerlin.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Südwestdeutscher Verlag für Hochschulschriften
Date d'édition
2009
Langue
anglais
ISBN 10 
3838110749
ISBN 13 
9783838110745
Reliure
Broché
Nombre de pages
112
Coordonnées du fabricant
non disponible
Personne responsable
non disponible