MicroRNA Regulation of Dendritic Cells: Experimental studies on the role of microRNAs in dendritic cell development and function - Couverture souple

Schnorfeil, Frauke Marie

Couverture souple

ISBN 10 : 3838131894 ISBN 13 : 9783838131894

Editeur : Sudwestdeutscher Verlag Fur Hochschulschriften AG, 2012

Synopsis

Dendritic cells (DCs) play a key role in the initiation of adaptive immune responses and the maintenance of immunological self-tolerance. Due to their therapeutic potential, understanding the mechanisms that guide DC differentiation and effector functions is important. The recent identification of posttranscriptional control of gene expression by microRNAs has added a novel layer of gene regulation that may be important in DC biology. The experimental work presented and discussed here indicates a role for microRNAs in DC regulation that is not covered by transcription factors. An essential role for microRNAs in DC lineage fate decisions, as well as in homeostasis, maturation and function of Langerhans cells (the epidermal DCs) is demonstrated. Thus, microRNAs regulate various aspects of DC biology and thereby contribute to the control of adaptive immune responses.

A propos du livre

À propos de l'auteur

Frauke Marie Schnorfeil, Dr. rer. nat., studied Biology focusing on Human Genetics and Immunology. In 2011, she received her doctoral degree from the LMU Munich, Germany, for her research on dendritic cells.

Détails de l'édition

• Éditeur: Sudwestdeutscher Verlag Fur Hochschulschriften AG
• Date d'édition: 2012
• Langue: anglais
• ISBN 10: 3838131894
• ISBN 13: 9783838131894
• Reliure: Broché
• Nombre de pages: 88
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible