This thesis is composed of three parts that are presented in a hierarchical order reflecting increasing organization level of the studied system. Gene regulation was studied at the single gene level first, extended to interacting transcriptional units and finally to its role within small regulatory networks. Our approach consists of an iterative experimental-based mathematical modeling based on promoter libraries with synthetic binding site sequences of variable affinities for selected transcriptional activators. We used such libraries to perform in vivo experiments using the yeast Saccharomyces cerevisiae in order to improve our theoretical models. The main goal of the work is the determination of gene system’s intrinsic properties like cooperativity coefficients and binding affinities of transcription factors to DNA regulatory sequences.
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Antoine Buetti-Dinh, Swiss, born 21st October 1984, in Paris, France.PhD in Physical Systems Biology, Institute of Molecular Life Sciences, University of Zurich.Master of Science in Biochemistry, Biology Track, Department of Biochemistry, University of Zurich.Bachelor of Science in Biochemistry, Biology Track.Department of Biochemistry.
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Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This thesis is composed of three parts that are presented in a hierarchical order reflecting increasing organization level of the studied system. Gene regulation was studied at the single gene level first, extended to interacting transcriptional units and finally to its role within small regulatory networks. Our approach consists of an iterative experimental-based mathematical modeling based on promoter libraries with synthetic binding site sequences of variable affinities for selected transcriptional activators. We used such libraries to perform in vivo experiments using the yeast Saccharomyces cerevisiae in order to improve our theoretical models. The main goal of the work is the determination of gene system's intrinsic properties like cooperativity coefficients and binding affinities of transcription factors to DNA regulatory sequences. 228 pp. Englisch. N° de réf. du vendeur 9783838132884
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Antoine Buetti-DinhAntoine Buetti-Dinh, Swiss, born 21st October 1984, in Paris, France.PhD in Physical Systems Biology, Institute of Molecular Life Sciences, University of Zurich.Master of Science in Biochemistry, Biology Track, Dep. N° de réf. du vendeur 5407570
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Taschenbuch. Etat : Neu. Gene Regulation by Numbers | Steady-State and Equilibrium Binding Applied to Gene Regulation Systems | Buetti-Dinh Antoine | Taschenbuch | Paperback | 228 S. | Englisch | 2015 | Südwestdeutscher Verlag für Hochschulschriften AG Co. KG | EAN 9783838132884 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu. N° de réf. du vendeur 106502517
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Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne
Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -This thesis is composed of three parts that are presented in a hierarchical order reflecting increasing organization level of the studied system. Gene regulation was studied at the single gene level first, extended to interacting transcriptional units and finally to its role within small regulatory networks. Our approach consists of an iterative experimental-based mathematical modeling based on promoter libraries with synthetic binding site sequences of variable affinities for selected transcriptional activators. We used such libraries to perform in vivo experiments using the yeast Saccharomyces cerevisiae in order to improve our theoretical models. The main goal of the work is the determination of gene system's intrinsic properties like cooperativity coefficients and binding affinities of transcription factors to DNA regulatory sequences.Books on Demand GmbH, Überseering 33, 22297 Hamburg 228 pp. Englisch. N° de réf. du vendeur 9783838132884
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Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - This thesis is composed of three parts that are presented in a hierarchical order reflecting increasing organization level of the studied system. Gene regulation was studied at the single gene level first, extended to interacting transcriptional units and finally to its role within small regulatory networks. Our approach consists of an iterative experimental-based mathematical modeling based on promoter libraries with synthetic binding site sequences of variable affinities for selected transcriptional activators. We used such libraries to perform in vivo experiments using the yeast Saccharomyces cerevisiae in order to improve our theoretical models. The main goal of the work is the determination of gene system's intrinsic properties like cooperativity coefficients and binding affinities of transcription factors to DNA regulatory sequences. N° de réf. du vendeur 9783838132884
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