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Optimal Cancer Screening: Life-Cycle Monte Carlo Simulations for the case of Colon and Rectum Cancers - Couverture souple

Gonzalez, Javier

 
9783838300894: Optimal Cancer Screening: Life-Cycle Monte Carlo Simulations for the case of Colon and Rectum Cancers
Couverture souple
ISBN 10 : 3838300890 ISBN 13 : 9783838300894
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

A dynamic stochastic model for colon and rectum cancer is developed to obtain the optimal ages to perform colonoscopies. The currently recommended guideline for colonoscopy is to test at ages 50, 60, 70, 80 and 90. Our Monte Carlo simulation yields a cost/life-year saved of $54,919.62 for the official policy. We ask the following: if we could reallocate the 5 tests between the ages of 50 and 90, which ages for testing would give the lowest cost/life-year saved? Of the 91,309 possible policies 43,026, or 47%, have a better cost per life-year saved than the currently recommended guidelines. The policy with the lowest cost is to test at the ages of 64, 71, 73, 79, 85 with a cost of $38,081.37 per life-year saved. An improvement of 30% in the cost/life-year saved. The framework developed in this paper can be further used to evaluate the cost effectiveness of current guidelines for other cancers. The policies can be personalized by sex and race to have better cost- effectiveness ratios. Finally, guidelines can be developed to equate cost per life-year saved across different cancers.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

A dynamic stochastic model for colon and rectum cancer is developed to obtain the optimal ages to perform colonoscopies. The currently recommended guideline for colonoscopy is to test at ages 50, 60, 70, 80 and 90. Our Monte Carlo simulation yields a cost/life-year saved of $54,919.62 for the official policy. We ask the following: if we could reallocate the 5 tests between the ages of 50 and 90, which ages for testing would give the lowest cost/life-year saved? Of the 91,309 possible policies 43,026, or 47%, have a better cost per life-year saved than the currently recommended guidelines. The policy with the lowest cost is to test at the ages of 64, 71, 73, 79, 85 with a cost of $38,081.37 per life-year saved. An improvement of 30% in the cost/life-year saved. The framework developed in this paper can be further used to evaluate the cost effectiveness of current guidelines for other cancers. The policies can be personalized by sex and race to have better cost- effectiveness ratios. Finally, guidelines can be developed to equate cost per life-year saved across different cancers.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3838300890
ISBN 13 
9783838300894
Reliure
Broché
Nombre de pages
64
Coordonnées du fabricant
non disponible
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