Articles liés à Nuclear and cytoplasmic control of the DNA damage checkpoint...

Nuclear and cytoplasmic control of the DNA damage checkpoint: A new way of looking at cell cycle control - Couverture souple

Dotiwala, Farokh

 
9783838302775: Nuclear and cytoplasmic control of the DNA damage checkpoint: A new way of looking at cell cycle control
Couverture souple
ISBN 10 : 383830277X ISBN 13 : 9783838302775
Editeur : LAP Lambert Academic Publishing, 2009

Synopsis

Cell cycle checkpoints are the means by which cells maintain their genomic integrity and resist factors that are potentially mutagenic. It is well known that there are different checkpoints for different stresses a cell could face, one of them being the DNA damage checkpoint. For long the activity of this checkpoint was thought to be limited to the nucleus. In this and other emerging studies it has now been established that the DNA damage checkpoint can regulate cell cycle arrest, nuclear positioning and movement by controlling cytoplasmic factors and events. This study establishes a novel regulatory mechanism of the DNA damage checkpoint involving vesicular transport system and cytoplasmic, non-proteosomal protein degradation. The study also focuses on the connection between the spindle assembly checkpoint (SAC) and the DNA damage checkpoint. To study this we generate an acentric chromosome with a single DNA double strand break on it. We find that budding yeast cells that have one chromosome with conditional GAL1-Cen centromere turned off cannot activate the SAC and both the sister chromatids of this chromosome get preferentially segregated to the mother cell.

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Présentation de l'éditeur

Cell cycle checkpoints are the means by which cells maintain their genomic integrity and resist factors that are potentially mutagenic. It is well known that there are different checkpoints for different stresses a cell could face, one of them being the DNA damage checkpoint. For long the activity of this checkpoint was thought to be limited to the nucleus. In this and other emerging studies it has now been established that the DNA damage checkpoint can regulate cell cycle arrest, nuclear positioning and movement by controlling cytoplasmic factors and events. This study establishes a novel regulatory mechanism of the DNA damage checkpoint involving vesicular transport system and cytoplasmic, non-proteosomal protein degradation. The study also focuses on the connection between the spindle assembly checkpoint (SAC) and the DNA damage checkpoint. To study this we generate an acentric chromosome with a single DNA double strand break on it. We find that budding yeast cells that have one chromosome with conditional GAL1-Cen centromere turned off cannot activate the SAC and both the sister chromatids of this chromosome get preferentially segregated to the mother cell.

Biographie de l'auteur

I left a career in medicine to follow my dream of bettering our understanding of diseases like cancer. My research as a Ph.D. student was in the field of DNA damage under the guidance of Prof. James Haber. We studied the cellular mechanisms involved in sensing and repairing the DNA damage, which if unchecked could lead to cell death or cancer.

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Éditeur
LAP Lambert Academic Publishing
Date d'édition
2009
Langue
anglais
ISBN 10 
383830277X
ISBN 13 
9783838302775
Reliure
Broché
Nombre de pages
188
Coordonnées du fabricant
non disponible
Personne responsable
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