Articles liés à Diamines in Catalysis and in Biological Systems: Analysis...

Diamines in Catalysis and in Biological Systems: Analysis and Applications - Couverture souple

Chagal, Leonid

 
9783838306520: Diamines in Catalysis and in Biological Systems: Analysis and Applications
Couverture souple
ISBN 10 : 383830652X ISBN 13 : 9783838306520
Editeur : LAP LAMBERT Academic Publishing, 2009

Synopsis

Currently there is a lot of interest in developing new methods for making chiral 1,2-diamines since they are building blocks not only for stereoselective catalysts, but also for a variety of therapeutic agents. Optically pure 1,2-diamines (or vicinal diamines) are used as organocatalysts in aldol condensation, Michael addition1-5 and Diels-Alder reactions or as metal ligands for stereoselective epoxidation, hydrogenation and dihydroxylation. In the realm of biology and biochemistry, diamine functionality is found in 1,2-diamino acids, β-lactam antibiotics and various pharmaceuticals. In chemotherapy, platinum 1,2-diamino complexes have long been used as antitumor agents. All these utilizations stimulated further research in the field of diamine synthesis. Numerous strategies have been developed to meet this need including coupling of bis-imines using low valent transition metals, preparation and subsequent reduction of diketones or addition of nitrogen sources to aziridine and epoxide moieties. This book describes novel methods which are more efficient and less cumbersome in preparation of chiral vicinal diamines.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Currently there is a lot of interest in developing new methods for making chiral 1,2-diamines since they are building blocks not only for stereoselective catalysts, but also for a variety of therapeutic agents. Optically pure 1,2-diamines (or vicinal diamines) are used as organocatalysts in aldol condensation, Michael addition1-5 and Diels-Alder reactions or as metal ligands for stereoselective epoxidation, hydrogenation and dihydroxylation. In the realm of biology and biochemistry, diamine functionality is found in 1,2-diamino acids, β-lactam antibiotics and various pharmaceuticals. In chemotherapy, platinum 1,2-diamino complexes have long been used as antitumor agents. All these utilizations stimulated further research in the field of diamine synthesis. Numerous strategies have been developed to meet this need including coupling of bis-imines using low valent transition metals, preparation and subsequent reduction of diketones or addition of nitrogen sources to aziridine and epoxide moieties. This book describes novel methods which are more efficient and less cumbersome in preparation of chiral vicinal diamines.

Biographie de l'auteur

2005- Honors B.Sc Biological Chemistry. University of Toronto 2007- Master of Science in Chemistry. University of Toronto

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2009
Langue
anglais
ISBN 10 
383830652X
ISBN 13 
9783838306520
Reliure
Broché
Nombre de pages
112
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne