Synthesis of Allicin, its Derivatives and Inclusion Complexes - Couverture souple

Nikolic, Vesna

Couverture souple

ISBN 10 : 3838310802 ISBN 13 : 9783838310800

Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

The main agents of the pharmacological activity of garlic (Allium sativum L.) are organosulfur compounds of which the most important one is allicin (diallylthiosulfinate). Allicin has a wide range of antibacterial and antifungal effects. It shows significant antioxidative and antitumor effect. Allicin is very unstable and depending on the external factors it is transformed into pharmacologically active derivatives. The most important are ajoenes and vinyldithiins. They take part in the inhibition of the thrombocyte aggregation, in the regulation of systolic and diastolic blood pressure, reduce the triglyceride and phospholipid levels and exhibit diuretic, antimicrobial, fibrinolytic and vasodilative effects. In exploring their stabilization, allicin complexes were synthesized with β-cyclodextrin and urea as inclusion complexes. The results obtained in this dissertation present a scientific contribution to the research of new pharmacologically active compounds that might, in the near future, find significant application in the pharmaceutical industry.

Détails de l'édition

• Éditeur: LAP LAMBERT Academic Publishing
• Date d'édition: 2012
• Langue: anglais
• ISBN 10: 3838310802
• ISBN 13: 9783838310800
• Reliure: Broché
• Nombre de pages: 76
• Coordonnées du fabricant: non disponible
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