NON-PROTEIN-CODING RNAS MEDIATE FINE-TUNED GENE EXPRESSION: VOLUME ONE: REGULATORY ROLES OF NATURAL ANTISENSE TRANSCRIPTS - Couverture souple

Faghihi, Mohammad Ali

 
9783838323947: NON-PROTEIN-CODING RNAS MEDIATE FINE-TUNED GENE EXPRESSION: VOLUME ONE: REGULATORY ROLES OF NATURAL ANTISENSE TRANSCRIPTS
Couverture souple
ISBN 10 : 3838323947 ISBN 13 : 9783838323947
Editeur : LAP Lambert Academic Publishing, 2009

Synopsis

Natural antisense transcripts: The human genome sequencing projects revealed that the human genome consist of over 3 billion DNA base pairs, but only contain 20,000?25,000 genes that are encoding proteins. Recent studies have revealed that eukaryotic genomes are almost entirely transcribed, generating an enormous number of non-protein-coding RNAs. Several classes of functional non-protein-coding RNAs have been identified in recent years. One prominent and complex class of regulatory RNAs is natural antisense transcripts. Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform regulatory RNA group, but instead belong to multiple categories with some common features. Recent evidence presented in this book indicates that antisense transcripts are frequently functional and use diverse transcriptional and post- transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Natural antisense transcripts: The human genome sequencing projects revealed that the human genome consist of over 3 billion DNA base pairs, but only contain 20,000?25,000 genes that are encoding proteins. Recent studies have revealed that eukaryotic genomes are almost entirely transcribed, generating an enormous number of non-protein-coding RNAs. Several classes of functional non-protein-coding RNAs have been identified in recent years. One prominent and complex class of regulatory RNAs is natural antisense transcripts. Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform regulatory RNA group, but instead belong to multiple categories with some common features. Recent evidence presented in this book indicates that antisense transcripts are frequently functional and use diverse transcriptional and post- transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP Lambert Academic Publishing
Date d'édition
2009
Langue
anglais
ISBN 10 
3838323947
ISBN 13 
9783838323947
Reliure
Broché
Nombre de pages
128
Coordonnées du fabricant
non disponible
Personne responsable
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