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Tetraaryl Substituted Bispidones:Synthesis and Stereochemistry - Couverture souple

Vijayakumar, V.; Kalaivani, K.; Varalakshmi, C.

 
9783838325989: Tetraaryl Substituted Bispidones:Synthesis and Stereochemistry
Couverture souple
ISBN 10 : 3838325982 ISBN 13 : 9783838325989
Editeur : LAP LAMBERT Academic Publishing, 2012

Synopsis

Heterocyclic compounds are widely prevalent in animal as well as in plant kingdom and they play vital role in metabolic processes. In recent years the 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonanes (Bispidones) one of the important class of nitrogen heterocycle, constitutes an interesting case for the study due to the presence of four aryl groups. In this present work new derivatives of 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonan-9-ones have been synthesized, stereochemistry and the chemical shift values have been assigned unambiguously using one and two Dimensional NMR studies; the stereochemistry of these compounds has been supported by X-ray diffraction studies also. These compounds are further converted into their corresponding 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonan-9-ol, characterized through 1H-NMR, 13C-NMR. The change of solvent system in these studies increased the yield into 90% (in literature it is up to 50-60%).

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Heterocyclic compounds are widely prevalent in animal as well as in plant kingdom and they play vital role in metabolic processes. In recent years the 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonanes (Bispidones) one of the important class of nitrogen heterocycle, constitutes an interesting case for the study due to the presence of four aryl groups. In this present work new derivatives of 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonan-9-ones have been synthesized, stereochemistry and the chemical shift values have been assigned unambiguously using one and two Dimensional NMR studies; the stereochemistry of these compounds has been supported by X-ray diffraction studies also. These compounds are further converted into their corresponding 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonan-9-ol, characterized through 1H-NMR, 13C-NMR. The change of solvent system in these studies increased the yield into 90% (in literature it is up to 50-60%).

Biographie de l'auteur

V. Vijayakumar, Professor, VIT University, completed his Ph.D at Gandhigram University, in Nitrogen Heterocycles currently focusing on the synthesis of various heterocycles and exploring their applications in medicinal field. Published more than 135 articles in international journals. K. Kalaivani who completed her M.Phil under VIT University.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2012
Langue
anglais
ISBN 10 
3838325982
ISBN 13 
9783838325989
Reliure
Broché
Nombre de pages
84
Coordonnées du fabricant
non disponible
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