?-Catenin, TCF, and ICAT: Novel Roles in T Cell Development, Function, and Aging - Couverture souple

Hossain, Mohammad Zulfiquer

 
9783838334509: ?-Catenin, TCF, and ICAT: Novel Roles in T Cell Development, Function, and Aging
Couverture souple
ISBN 10 : 3838334507 ISBN 13 : 9783838334509
Editeur : LAP Lambert Academic Publishing, 2010

Synopsis

In addition to working together to drive expression of target genes, ?-catenin and TCF often work independently of each other. They both regulate several stages of T cell development, but their mode of action remains poorly understood. To study the specific role of ?-catenin-TCF interactions in T cells, we generated transgenic mice that express ICAT, a naturally occurring inhibitor of ?-catenin-TCF interactions, in the T cell lineage. We found that ?-catenin-TCF interactions are important for thymocyte survival, but not for proliferation or differentiation. Interestingly, thymocyte aging slows down in ICAT-Tg mice, suggesting a role for ?-catenin-TCF interactions in normal thymic involution. We also discovered that ?-catenin-TCF interactions provide survival signals to activated T cells and promote differentiation of activated CD4 T cells into the default Th2 lineage. However, TCF represses Th1 differentiation independently of its interaction with ?-catenin. This study, thus, provides novel insights into the role of ?-catenin and TCF in T cell development, function, and aging, and should of interest to immunologists, developmental biologists, and gerontologists alike.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

In addition to working together to drive expression of target genes, ?-catenin and TCF often work independently of each other. They both regulate several stages of T cell development, but their mode of action remains poorly understood. To study the specific role of ?-catenin-TCF interactions in T cells, we generated transgenic mice that express ICAT, a naturally occurring inhibitor of ?-catenin-TCF interactions, in the T cell lineage. We found that ?-catenin-TCF interactions are important for thymocyte survival, but not for proliferation or differentiation. Interestingly, thymocyte aging slows down in ICAT-Tg mice, suggesting a role for ?-catenin-TCF interactions in normal thymic involution. We also discovered that ?-catenin-TCF interactions provide survival signals to activated T cells and promote differentiation of activated CD4 T cells into the default Th2 lineage. However, TCF represses Th1 differentiation independently of its interaction with ?-catenin. This study, thus, provides novel insights into the role of ?-catenin and TCF in T cell development, function, and aging, and should of interest to immunologists, developmental biologists, and gerontologists alike.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP Lambert Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3838334507
ISBN 13 
9783838334509
Reliure
Broché
Nombre de pages
196
Coordonnées du fabricant
non disponible
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