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A Functional Study of Notch Signaling in Brain Cancer Stem-like Cells - Couverture souple

Kristoffersen, Karina

 
9783838346144: A Functional Study of Notch Signaling in Brain Cancer Stem-like Cells
Couverture souple
ISBN 10 : 3838346149 ISBN 13 : 9783838346144
Editeur : LAP Lambert Academic Publishing, 2010

Synopsis

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults and confers a dismal prognosis. Despite intense effort, treatment remains a significant therapeutic challenge and new modalities are desperately needed. In recent years a population of cancer cells with neural stem cell (NSC)-like properties has been reported in GBM. It is hypothesized that these so- called brain cancer stem-like cells (bCSC) are involved in brain tumor initiation, progression and treatment resistance. The Notch signaling pathway is known to be important in maintaining an undifferentiated pool of normal NSC and in determination of cell fate. Several recent data implicate a functional role for Notch signaling in GBM cells and when considering its role in normal NSC, the Notch signaling pathway might be an appropriate target for bCSC directed GBM therapy. The aim of the present project was to establish and characterize GBM stem-like cell cultures from xenograft tumors originating from human primary GBM, and subsequently investigate the significance of Notch expression and activation in these cultures.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults and confers a dismal prognosis. Despite intense effort, treatment remains a significant therapeutic challenge and new modalities are desperately needed. In recent years a population of cancer cells with neural stem cell (NSC)-like properties has been reported in GBM. It is hypothesized that these so- called brain cancer stem-like cells (bCSC) are involved in brain tumor initiation, progression and treatment resistance. The Notch signaling pathway is known to be important in maintaining an undifferentiated pool of normal NSC and in determination of cell fate. Several recent data implicate a functional role for Notch signaling in GBM cells and when considering its role in normal NSC, the Notch signaling pathway might be an appropriate target for bCSC directed GBM therapy. The aim of the present project was to establish and characterize GBM stem-like cell cultures from xenograft tumors originating from human primary GBM, and subsequently investigate the significance of Notch expression and activation in these cultures.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP Lambert Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3838346149
ISBN 13 
9783838346144
Reliure
Broché
Nombre de pages
124
Coordonnées du fabricant
non disponible
Personne responsable
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