Articles liés à Gene expression during carcinogenesis: A bioinformatics...

Gene expression during carcinogenesis: A bioinformatics perspective: An analysis of the global patterns of changes in the gene expression associated with genesis of cancer - Couverture souple

Manyam, Ganiraju; Baranova, Ancha

 
9783838350899: Gene expression during carcinogenesis: A bioinformatics perspective: An analysis of the global patterns of changes in the gene expression associated with genesis of cancer
Couverture souple
ISBN 10 : 3838350898 ISBN 13 : 9783838350899
Editeur : LAP Lambert Academic Publishing, 2010

Synopsis

Cancer arises from a stepwise accumulation of genetic changes through expansion of the malignant cell clones in the population of pre-malignant cells undergoing Darwinian selection process. In other words, cancer is an outcome of continuous and random acquisition of the changes in the genomes of individual cells. These modifications gradually and progressively change the phenotype of the normal cell making it more malignant through a loss of an overall stability of genome. The book summarizes bioinformatic methods to analyze the most general features of the malignant cell investigating molecular phenomena common for all tumor cells, with no regard to the characteristics related to tumor?s tissue of origin. The results obtained in three independent modules of the book enhance a general understanding of cancer as an expression system comprising of the components dynamically interacting with each other. These results along with novel tools for in silico analysis of the cancer cell described in the book provide novel avenues for the functional genomics and systems biology of cancer and may be of help for large-scale computational modeling of cancer.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Cancer arises from a stepwise accumulation of genetic changes through expansion of the malignant cell clones in the population of pre-malignant cells undergoing Darwinian selection process. In other words, cancer is an outcome of continuous and random acquisition of the changes in the genomes of individual cells. These modifications gradually and progressively change the phenotype of the normal cell making it more malignant through a loss of an overall stability of genome. The book summarizes bioinformatic methods to analyze the most general features of the malignant cell investigating molecular phenomena common for all tumor cells, with no regard to the characteristics related to tumor?s tissue of origin. The results obtained in three independent modules of the book enhance a general understanding of cancer as an expression system comprising of the components dynamically interacting with each other. These results along with novel tools for in silico analysis of the cancer cell described in the book provide novel avenues for the functional genomics and systems biology of cancer and may be of help for large-scale computational modeling of cancer.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP Lambert Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3838350898
ISBN 13 
9783838350899
Reliure
Broché
Nombre de pages
216
Coordonnées du fabricant
non disponible
Personne responsable
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