Interaction of HIV Protease Inhibitor with Hepatic Drug Transporters: Characterization of cell culture based models for hepatic drug transporters mediated drug interaction study - Couverture souple

YE, Zhi-wei

 
9783838354293: Interaction of HIV Protease Inhibitor with Hepatic Drug Transporters: Characterization of cell culture based models for hepatic drug transporters mediated drug interaction study
Couverture souple
ISBN 10 : 383835429X ISBN 13 : 9783838354293
Editeur : LAP Lambert Academic Publishing, 2010

Synopsis

In the past decades, drug metabolizing enzymes (DME) and their role in drug interaction have been intensively investigated. Apart from DME, transporters are also involved in the absorption, distribution, and excretion of drugs; this implies that (pharmacokinetic) drug interactions may be mediated by transporters as well. However a less systematic approach is used for transporter-related drug elimination and interactions. This can be attributed to the fact that preclinical model systems to study transporter-based drug interactions differ from those typically used for metabolism- based interactions. In addition specific inhibitors and substrates are often lacking for transporters. In this research, we focused on characterizing a fluorescent transporter substrate (fluorescent bile salt analogue) with respect to its in vitro hepatobiliary disposition in various in vitro models. In addition, the utility of this probe substrate for assessment of hepatic transporter mediated drug interactions by using HIV Protease inhibitor as model interacting compounds was also investigated.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

In the past decades, drug metabolizing enzymes (DME) and their role in drug interaction have been intensively investigated. Apart from DME, transporters are also involved in the absorption, distribution, and excretion of drugs; this implies that (pharmacokinetic) drug interactions may be mediated by transporters as well. However a less systematic approach is used for transporter-related drug elimination and interactions. This can be attributed to the fact that preclinical model systems to study transporter-based drug interactions differ from those typically used for metabolism- based interactions. In addition specific inhibitors and substrates are often lacking for transporters. In this research, we focused on characterizing a fluorescent transporter substrate (fluorescent bile salt analogue) with respect to its in vitro hepatobiliary disposition in various in vitro models. In addition, the utility of this probe substrate for assessment of hepatic transporter mediated drug interactions by using HIV Protease inhibitor as model interacting compounds was also investigated.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP Lambert Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
383835429X
ISBN 13 
9783838354293
Reliure
Broché
Nombre de pages
156
Coordonnées du fabricant
non disponible
Personne responsable
KreGa Onlinehandel GmbH
4950000000000
info@krega-onlinehandel.de

Birkenweg 31
Brakel
33034
Allemagne