CD38 AS A PROGNOSTIC FACTOR IN B-CELL CHRONIC LYMPHOCYTIC LEUKAEMIA: CORELATION WITH IgVH GENE MUTATIONAL STATUS - Couverture souple

NABIH, MOSTAFA

 
9783838364087: CD38 AS A PROGNOSTIC FACTOR IN B-CELL CHRONIC LYMPHOCYTIC LEUKAEMIA: CORELATION WITH IgVH GENE MUTATIONAL STATUS
Couverture souple
ISBN 10 : 3838364082 ISBN 13 : 9783838364087
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

Chronic lymphocytic leukaemia follows an extremely variable clinical course with overall survival times ranging from months to decades, so there is a need to identify markers that may help to refine outcome prediction for these individuals. One of the most important molecular genetics parameters defining pathogenic and prognostic subgroups of Chronic lymphocytic leukaemia is the mutation status of the IgVH genes. CD38 expression has demonstrated a highly predictive prognostic value and can be used as a convenient and accurate predictor of IgVH gene mutational status. However, because IgVH gene mutational status assay is characterized by its technical complexity, high cost and needs for high level of expertise while CD38 percent expression can be determined more conveniently, rapidly and cheaper than IgVH gene mutational status, it offer the possibility of a substitute for IgVH gene mutations analysis. Moreover it may be the preferred adjunct to the current staging systems. Indeed, the results of this simple test should enable physicians to predict with considerable accuracy whether a patient is likely to have a favorable or unfavorable clinical course.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Chronic lymphocytic leukaemia follows an extremely variable clinical course with overall survival times ranging from months to decades, so there is a need to identify markers that may help to refine outcome prediction for these individuals. One of the most important molecular genetics parameters defining pathogenic and prognostic subgroups of Chronic lymphocytic leukaemia is the mutation status of the IgVH genes. CD38 expression has demonstrated a highly predictive prognostic value and can be used as a convenient and accurate predictor of IgVH gene mutational status. However, because IgVH gene mutational status assay is characterized by its technical complexity, high cost and needs for high level of expertise while CD38 percent expression can be determined more conveniently, rapidly and cheaper than IgVH gene mutational status, it offer the possibility of a substitute for IgVH gene mutations analysis. Moreover it may be the preferred adjunct to the current staging systems. Indeed, the results of this simple test should enable physicians to predict with considerable accuracy whether a patient is likely to have a favorable or unfavorable clinical course.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3838364082
ISBN 13 
9783838364087
Reliure
Broché
Nombre de pages
168
Coordonnées du fabricant
non disponible
Personne responsable
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