Articles liés à Real-Space Methods to Solve Protein Structures: Improved...

Real-Space Methods to Solve Protein Structures: Improved Density-Modification Techniques for Phasing and Phase Extension in Protein Crystallography. - Couverture souple

Foadi, James

 
9783838372686: Real-Space Methods to Solve Protein Structures: Improved Density-Modification Techniques for Phasing and Phase Extension in Protein Crystallography.
Couverture souple
ISBN 10 : 3838372689 ISBN 13 : 9783838372686
Editeur : LAP LAMBERT Academic Publishing, 2010

Synopsis

This book reproduces work written for a PhD thesis. It introduces new theoretical methods for the solution of protein structures through the processing and interpretation of crystallographic data coming from high-resolution X-ray diffraction experiments. Only data for the native protein are used, i.e. the procedure here explained and tested implies ab initio solution. This method has been implemented in a computer package, ACORN, whose main underlying concept is that a proper structural fragment, equivalent to 5-10% of the structure being studied, can give rise to enough information to start a process of Fourier recycling and density modification in real space, leading to the solution of the structure. Tests performed on RNAse AP1 in this thesis and on other structures in another context, have proved that ACORN is a robust procedure and that it can be adapted to many different situations.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

This book reproduces work written for a PhD thesis. It introduces new theoretical methods for the solution of protein structures through the processing and interpretation of crystallographic data coming from high-resolution X-ray diffraction experiments. Only data for the native protein are used, i.e. the procedure here explained and tested implies ab initio solution. This method has been implemented in a computer package, ACORN, whose main underlying concept is that a proper structural fragment, equivalent to 5-10% of the structure being studied, can give rise to enough information to start a process of Fourier recycling and density modification in real space, leading to the solution of the structure. Tests performed on RNAse AP1 in this thesis and on other structures in another context, have proved that ACORN is a robust procedure and that it can be adapted to many different situations.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
LAP LAMBERT Academic Publishing
Date d'édition
2010
Langue
anglais
ISBN 10 
3838372689
ISBN 13 
9783838372686
Reliure
Broché
Nombre de pages
188
Coordonnées du fabricant
non disponible
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